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Literature DB >> 22441839

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy.

Fei Yi¹, Guang-Hui Liu, Juan Carlos Izpisua Belmonte.

Abstract

Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

Entities: Disease Species

Mesh：

Year: 2012 PMID： 22441839 PMCID： PMC4875479 DOI： 10.1007/s13238-012-2918-4

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

28 in total

1. Stem cells and drug discovery: the beginning of a new era?

Authors: Lee L Rubin
Journal: Cell Date: 2008-02-22 Impact factor: 41.582

Review 2. In vivo modeling of human liver for pharmacological study using humanized mouse.

Authors: Katsutoshi Yoshizato; Chise Tateno
Journal: Expert Opin Drug Metab Toxicol Date: 2009-11 Impact factor: 4.481

3. Human-induced pluripotent stem cells as a source of hepatocyte-like cells: new kids on the block.

Authors: C Busletta; E Novo; M Parola
Journal: Hepatol Int Date: 2011-07-23 Impact factor: 6.047

4. Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes.

Authors: Hua Liu; Zhaohui Ye; Yonghak Kim; Saul Sharkis; Yoon-Young Jang
Journal: Hepatology Date: 2010-05 Impact factor: 17.425

5. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells.

Authors: Karim Si-Tayeb; Fallon K Noto; Masato Nagaoka; Jixuan Li; Michele A Battle; Christine Duris; Paula E North; Stephen Dalton; Stephen A Duncan
Journal: Hepatology Date: 2010-01 Impact factor: 17.425

6. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells.

Authors: Zhihua Song; Jun Cai; Yanxia Liu; Dongxin Zhao; Jun Yong; Shuguang Duo; Xijun Song; Yushan Guo; Yang Zhao; Han Qin; Xiaolei Yin; Chen Wu; Jie Che; Shichun Lu; Mingxiao Ding; Hongkui Deng
Journal: Cell Res Date: 2009-09-08 Impact factor: 25.617

7. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs.

Authors: Guang-Hui Liu; Keiichiro Suzuki; Jing Qu; Ignacio Sancho-Martinez; Fei Yi; Mo Li; Sachin Kumar; Emmanuel Nivet; Jessica Kim; Rupa Devi Soligalla; Ilir Dubova; April Goebl; Nongluk Plongthongkum; Ho-Lim Fung; Kun Zhang; Jeanne F Loring; Louise C Laurent; Juan Carlos Izpisua Belmonte
Journal: Cell Stem Cell Date: 2011-05-19 Impact factor: 24.633

Review 8. Generation and regeneration of cells of the liver and pancreas.

Authors: Kenneth S Zaret; Markus Grompe
Journal: Science Date: 2008-12-05 Impact factor: 47.728

Review 9. Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease.

Authors: Yong Soon Chun; Pooja Chaudhari; Yoon-Young Jang
Journal: Int J Biol Sci Date: 2010-12-14 Impact factor: 6.580

10. Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.

Authors: Kosuke Yusa; S Tamir Rashid; Helene Strick-Marchand; Ignacio Varela; Pei-Qi Liu; David E Paschon; Elena Miranda; Adriana Ordóñez; Nicholas R F Hannan; Foad J Rouhani; Sylvie Darche; Graeme Alexander; Stefan J Marciniak; Noemi Fusaki; Mamoru Hasegawa; Michael C Holmes; James P Di Santo; David A Lomas; Allan Bradley; Ludovic Vallier
Journal: Nature Date: 2011-10-12 Impact factor: 49.962

17 in total

Review 1. In vitro platforms for evaluating liver toxicity.

Authors: Shyam Sundhar Bale; Lawrence Vernetti; Nina Senutovitch; Rohit Jindal; Manjunath Hegde; Albert Gough; William J McCarty; Ahmet Bakan; Abhinav Bhushan; Tong Ying Shun; Inna Golberg; Richard DeBiasio; Berk Osman Usta; D Lansing Taylor; Martin L Yarmush
Journal: Exp Biol Med (Maywood) Date: 2014-04-24

2. Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System.

Authors: Michael K Conway; Michael J Gerger; Erin E Balay; Rachel O'Connell; Seth Hanson; Neil J Daily; Tetsuro Wakatsuki
Journal: J Vis Exp Date: 2015-05-14 Impact factor: 1.355

3. Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.

Authors: Akihiro Asai; Eitaro Aihara; Carey Watson; Reena Mourya; Tatsuki Mizuochi; Pranavkumar Shivakumar; Kieran Phelan; Christopher Mayhew; Michael Helmrath; Takanori Takebe; James Wells; Jorge A Bezerra
Journal: Development Date: 2017-03-15 Impact factor: 6.868

4. Establishment of hepatic and neural differentiation platforms of Wilson's disease specific induced pluripotent stem cells.

Authors: Fei Yi; Jing Qu; Mo Li; Keiichiro Suzuki; Na Young Kim; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Journal: Protein Cell Date: 2012-07-18 Impact factor: 14.870

Review 5. Physiologically relevant organs on chips.

Authors: Kyungsuk Yum; Soon Gweon Hong; Kevin E Healy; Luke P Lee
Journal: Biotechnol J Date: 2013-12-04 Impact factor: 4.677

Review 6. Liver 'organ on a chip'.

Authors: Colin H Beckwitt; Amanda M Clark; Sarah Wheeler; D Lansing Taylor; Donna B Stolz; Linda Griffith; Alan Wells
Journal: Exp Cell Res Date: 2017-12-29 Impact factor: 3.905