BACKGROUND: To examine recent trends in gallbladder cancer (GBC) in the general population in the Western world, cancer registration data on GBC in the Netherlands were analyzed. METHODS: Trends in incidence, treatment and survival, according to gender, age and stage of disease, between 1989 and 2008 for 3,917 patients were studied. Rates were age-standardized to the European standard population (European Standardized Rates - ESR). RESULTS: The incidence rate for GBC in the Netherlands decreased rapidly during the period of 1989-2008, except for males younger than 60 years. Overall survival remained stable, short-term (3-month) and long-term (5-year) relative survival among surgically treated patients increased significantly. Treatment patterns for GBC changed. Surgery decreased from 55% in 1989 to 38% in 2008 (p < 0.001). Chemotherapy and/or irradiation increased from 1.0 to 5.8% (p < 0.001). Receiving best supportive care increased from 44% in 1989 to 57% in 2008 (p < 0.001). CONCLUSION: The incidence rate for GBC in the Netherlands has decreased rapidly. Treatment patterns for GBC have changed and survival among surgically treated patients has increased.
BACKGROUND: To examine recent trends in gallbladder cancer (GBC) in the general population in the Western world, cancer registration data on GBC in the Netherlands were analyzed. METHODS: Trends in incidence, treatment and survival, according to gender, age and stage of disease, between 1989 and 2008 for 3,917 patients were studied. Rates were age-standardized to the European standard population (European Standardized Rates - ESR). RESULTS: The incidence rate for GBC in the Netherlands decreased rapidly during the period of 1989-2008, except for males younger than 60 years. Overall survival remained stable, short-term (3-month) and long-term (5-year) relative survival among surgically treated patients increased significantly. Treatment patterns for GBC changed. Surgery decreased from 55% in 1989 to 38% in 2008 (p < 0.001). Chemotherapy and/or irradiation increased from 1.0 to 5.8% (p < 0.001). Receiving best supportive care increased from 44% in 1989 to 57% in 2008 (p < 0.001). CONCLUSION: The incidence rate for GBC in the Netherlands has decreased rapidly. Treatment patterns for GBC have changed and survival among surgically treated patients has increased.
Authors: B J G A Corten; S Alexander; P H van Zwam; W K G Leclercq; R M H Roumen; G D Slooter Journal: J Gastrointest Surg Date: 2018-08-21 Impact factor: 3.452
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Authors: Alexander Stein; Dirk Arnold; John Bridgewater; David Goldstein; Lars Henrik Jensen; Heinz-Josef Klümpen; Ansgar W Lohse; Björn Nashan; John Primrose; Silke Schrum; Jenny Shannon; Eik Vettorazzi; Henning Wege Journal: BMC Cancer Date: 2015-07-31 Impact factor: 4.430
Authors: Elise de Savornin Lohman; Tessa de Bitter; Rob Verhoeven; Lydia van der Geest; Jeroen Hagendoorn; Nadia Haj Mohammad; Freek Daams; Heinz-Josef Klümpen; Thomas van Gulik; Joris Erdmann; Marieke de Boer; Frederik Hoogwater; Bas Groot Koerkamp; Andries Braat; Joanne Verheij; Iris Nagtegaal; Cornelis van Laarhoven; Peter van den Boezem; Rachel van der Post; Philip de Reuver Journal: Cancers (Basel) Date: 2020-04-09 Impact factor: 6.639