BACKGROUND: Although low circulating 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and obesity, the relations between these 3 variables have not been completely resolved. OBJECTIVE: The objective was to compare circulating 25(OH)D concentrations in apparently healthy individuals who were matched for degree of obesity or insulin sensitivity. DESIGN: This was a case-control study in which 78 apparently healthy individuals were classified as being normal weight (NW) or obese (OB) on the basis of their BMI and as being insulin sensitive (IS) or insulin resistant (IR) on the basis of their steady state plasma glucose (SSPG) concentration during the insulin suppression test. RESULTS: Groups did not differ in terms of age, sex distribution, race, or mean (± SD) plasma 25(OH)D concentration. Values for 25(OH)D were 32 ± 10, 30 ± 10, and 28 ± 8 ng/mL in NW-IS, OB-IS, and OB-IR groups, respectively. These concentrations were essentially identical when comparing IR with IS subjects matched for BMI or when comparing OB with NW subjects matched for SSPG. Concentrations of 25(OH)D ≤ 30 ng/mL were somewhat more common in OB subjects than in NW subjects (54% compared with 35%), but SSPG concentrations were not different within either the IR or IS groups when subgroups with 25(OH)D concentrations ≤ 30 or > 30 ng/mL were compared. CONCLUSIONS: In 78 individuals, 47% of whom were vitamin D deficient or insufficient (≤ 30 ng/mL), 25(OH)D concentrations did not vary with differences in insulin sensitivity (SSPG concentration) when matched for BMI (OB-IR compared with OB-IS). Similarly, when matched for SSPG concentrations, plasma 25(OH)D concentrations were not different in NW or OB individuals (NW-IS compared with OB-IS).
BACKGROUND: Although low circulating 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with insulin resistance and obesity, the relations between these 3 variables have not been completely resolved. OBJECTIVE: The objective was to compare circulating 25(OH)D concentrations in apparently healthy individuals who were matched for degree of obesity or insulin sensitivity. DESIGN: This was a case-control study in which 78 apparently healthy individuals were classified as being normal weight (NW) or obese (OB) on the basis of their BMI and as being insulin sensitive (IS) or insulin resistant (IR) on the basis of their steady state plasma glucose (SSPG) concentration during the insulin suppression test. RESULTS: Groups did not differ in terms of age, sex distribution, race, or mean (± SD) plasma 25(OH)D concentration. Values for 25(OH)D were 32 ± 10, 30 ± 10, and 28 ± 8 ng/mL in NW-IS, OB-IS, and OB-IR groups, respectively. These concentrations were essentially identical when comparing IR with IS subjects matched for BMI or when comparing OB with NW subjects matched for SSPG. Concentrations of 25(OH)D ≤ 30 ng/mL were somewhat more common in OB subjects than in NW subjects (54% compared with 35%), but SSPG concentrations were not different within either the IR or IS groups when subgroups with 25(OH)D concentrations ≤ 30 or > 30 ng/mL were compared. CONCLUSIONS: In 78 individuals, 47% of whom were vitamin Ddeficient or insufficient (≤ 30 ng/mL), 25(OH)D concentrations did not vary with differences in insulin sensitivity (SSPG concentration) when matched for BMI (OB-IR compared with OB-IS). Similarly, when matched for SSPG concentrations, plasma 25(OH)D concentrations were not different in NW or OB individuals (NW-IS compared with OB-IS).
Authors: Reema Jain; Pamela R von Hurst; Welma Stonehouse; Donald R Love; Colleen M Higgins; Jane Coad Journal: Metabolism Date: 2011-08-25 Impact factor: 8.694
Authors: S Lillioja; D M Mott; M Spraul; R Ferraro; J E Foley; E Ravussin; W C Knowler; P H Bennett; C Bogardus Journal: N Engl J Med Date: 1993-12-30 Impact factor: 91.245
Authors: E Cipponeri; N Vitturi; V Mariano; F Boscari; S Galasso; C Crepaldi; G P Fadini; S Vigili de Kreutzenberg; M C Marescotti; E Iori; F Cavallin; L Sartori; A Baritussio; A Avogaro; D Bruttomesso Journal: J Endocrinol Invest Date: 2019-03-07 Impact factor: 4.256
Authors: Emanuela A Greco; Davide Francomano; Rachele Fornari; Chiara Marocco; Carla Lubrano; Vincenza Papa; Francesca Wannenes; Luigi Di Luigi; Lorenzo M Donini; Andrea Lenzi; Antonio Aversa; Silvia Migliaccio Journal: World J Diabetes Date: 2013-04-15
Authors: M Reyman; A A Verrijn Stuart; M van Summeren; M Rakhshandehroo; R Nuboer; F K de Boer; H J van den Ham; E Kalkhoven; B Prakken; H S Schipper Journal: Int J Obes (Lond) Date: 2013-05-20 Impact factor: 5.095
Authors: Javier de las Heras; Kumaravel Rajakumar; SoJung Lee; Fida Bacha; Michael F Holick; Silva A Arslanian Journal: Diabetes Care Date: 2013-01-22 Impact factor: 19.112