Literature DB >> 22440845

Lethal mutagenesis of viruses.

Celia Perales1, Verónica Martín, Esteban Domingo.   

Abstract

Lethal mutagenesis aims at extinguishing viruses by increased mutagenesis prompted by virus-specific mutagenic agents, mainly nucleoside analogues. It is derived from the error threshold relationship of quasispecies theory, and it is slowly finding its way towards a clinical application. We summarize the current situation of research in this field of antiviral therapy.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22440845     DOI： 10.1016/j.coviro.2011.09.001

Source DB:  PubMed          Journal:  Curr Opin Virol        ISSN： 1879-6257            Impact factor:   7.090


  16 in total

1.  Evaluation of anti-HIV-1 mutagenic nucleoside analogues.

Authors:  Valérie Vivet-Boudou; Catherine Isel; Yazan El Safadi; Redmond P Smyth; Géraldine Laumond; Christiane Moog; Jean-Christophe Paillart; Roland Marquet
Journal:  J Biol Chem       Date:  2014-11-14       Impact factor: 5.157

2.  Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine.

Authors:  Deyu Li; Bogdan I Fedeles; Vipender Singh; Chunte Sam Peng; Katherine J Silvestre; Allison K Simi; Jeffrey H Simpson; Andrei Tokmakoff; John M Essigmann
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-28       Impact factor: 11.205

Review 3.  Complexities of Viral Mutation Rates.

Authors:  Kayla M Peck; Adam S Lauring
Journal:  J Virol       Date:  2018-06-29       Impact factor: 5.103

4.  Two-dimensional IR spectroscopy of the anti-HIV agent KP1212 reveals protonated and neutral tautomers that influence pH-dependent mutagenicity.

Authors:  Chunte Sam Peng; Bogdan I Fedeles; Vipender Singh; Deyu Li; Tiffany Amariuta; John M Essigmann; Andrei Tokmakoff
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-02       Impact factor: 11.205

5.  T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro.

Authors:  Tatiana Baranovich; Sook-San Wong; Jianling Armstrong; Henju Marjuki; Richard J Webby; Robert G Webster; Elena A Govorkova
Journal:  J Virol       Date:  2013-01-16       Impact factor: 5.103

6.  Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis.

Authors:  Jonathan M O Rawson; Sean R Landman; Cavan S Reilly; Laurent Bonnac; Steven E Patterson; Louis M Mansky
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

7.  Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA.

Authors:  Ji Huang; Craig J Yennie; Sarah Delaney
Journal:  Chem Res Toxicol       Date:  2015-11-24       Impact factor: 3.739

8.  Ecology and Evolution of Betacoronaviruses.

Authors:  Eduardo Rodríguez-Román; Adrian J Gibbs
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

9.  Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

Authors:  Everett Clinton Smith; Hervé Blanc; Matthew C Surdel; Marco Vignuzzi; Mark R Denison
Journal:  PLoS Pathog       Date:  2013-08-15       Impact factor: 6.823

Review 10.  Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity.

Authors:  Everett Clinton Smith; Mark R Denison
Journal:  PLoS Pathog       Date:  2013-12-05       Impact factor: 6.823
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