Literature DB >> 22437878

Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells.

Jaewook Chung1, Shengdar Tsai, Andra H James, Betty H Thames, Stephanie Shytle, Jorge A Piedrahita.   

Abstract

PRIM2, encoding a subunit of primase involved in DNA replication and transcription, is expressed in the placenta and is crucial for mammalian development and growth. Its role in placental function is not well understood. Recently, PRIM2 was reported as imprinted in human white blood cells (WBC). We report here our failure to confirm imprinting of the PRIM2 locus in human placenta or WBC. The discordance between our results and those of others are likely due to an incorrectly annotated PRIM2 pseudogene found in the human genome database.

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Year:  2012        PMID： 22437878      PMCID： PMC3368808          DOI： 10.4161/epi.19777

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  20 in total

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2.  Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.

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Journal:  Placenta       Date:  2010-12-22       Impact factor: 3.481

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Journal:  Trends Genet       Date:  1991-02       Impact factor: 11.639

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Journal:  J Biol Chem       Date:  1993-12-15       Impact factor: 5.157

5.  Completion of mouse embryogenesis requires both the maternal and paternal genomes.

Authors:  J McGrath; D Solter
Journal:  Cell       Date:  1984-05       Impact factor: 41.582

6.  Genome-wide prediction of imprinted murine genes.

Authors:  Philippe P Luedi; Alexander J Hartemink; Randy L Jirtle
Journal:  Genome Res       Date:  2005-06       Impact factor: 9.043

7.  The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.

Authors:  Laura K Zerbe; Robert D Kuchta
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8.  A gene atlas of the mouse and human protein-encoding transcriptomes.

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Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-09       Impact factor: 11.205

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Journal:  Eur J Biochem       Date:  1994-06-15

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Journal:  Genomics       Date:  1995-07-20       Impact factor: 5.736
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2.  Whole exome sequencing analysis for mutations in isolated type III biliary atresia patients.

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3.  Detection of Imprinted Genes by Single-Cell Allele-Specific Gene Expression.

Authors:  Federico A Santoni; Georgios Stamoulis; Marco Garieri; Emilie Falconnet; Pascale Ribaux; Christelle Borel; Stylianos E Antonarakis
Journal:  Am J Hum Genet       Date:  2017-02-09       Impact factor: 11.025

4.  The complex genetics of gait speed: genome-wide meta-analysis approach.

Authors:  Dan Ben-Avraham; David Karasik; Joe Verghese; Kathryn L Lunetta; Jennifer A Smith; John D Eicher; Rotem Vered; Joris Deelen; Alice M Arnold; Aron S Buchman; Toshiko Tanaka; Jessica D Faul; Maria Nethander; Myriam Fornage; Hieab H Adams; Amy M Matteini; Michele L Callisaya; Albert V Smith; Lei Yu; Philip L De Jager; Denis A Evans; Vilmundur Gudnason; Albert Hofman; Alison Pattie; Janie Corley; Lenore J Launer; Davis S Knopman; Neeta Parimi; Stephen T Turner; Stefania Bandinelli; Marian Beekman; Danielle Gutman; Lital Sharvit; Simon P Mooijaart; David C Liewald; Jeanine J Houwing-Duistermaat; Claes Ohlsson; Matthijs Moed; Vincent J Verlinden; Dan Mellström; Jos N van der Geest; Magnus Karlsson; Dena Hernandez; Rebekah McWhirter; Yongmei Liu; Russell Thomson; Gregory J Tranah; Andre G Uitterlinden; David R Weir; Wei Zhao; John M Starr; Andrew D Johnson; M Arfan Ikram; David A Bennett; Steven R Cummings; Ian J Deary; Tamara B Harris; Sharon L R Kardia; Thomas H Mosley; Velandai K Srikanth; Beverly G Windham; Ann B Newman; Jeremy D Walston; Gail Davies; Daniel S Evans; Eline P Slagboom; Luigi Ferrucci; Douglas P Kiel; Joanne M Murabito; Gil Atzmon
Journal:  Aging (Albany NY)       Date:  2017-01-10       Impact factor: 5.955
  4 in total

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