Literature DB >> 22430962

In vitro activities of clindamycin, imipenem, metronidazole, and piperacillin-tazobactam against susceptible and resistant isolates of Bacteroides fragilis evaluated by kill kinetics.

Reiner Schaumann1, Matthias Funke, Eva Janssen, Arne C Rodloff.   

Abstract

The aim of the present study was to investigate the activities of clindamycin, imipenem, metronidazole, and piperacillin-tazobactam against 12 Bacteroides fragilis isolates (resistant and susceptible strains) by kill kinetics over 24 h. In contrast to the other antimicrobial agents, clindamycin did not affect strains with MICs of >8.0 μg/ml. For those strains with MICs of ≤ 8.0 μg/ml, all employed antibiotics except clindamycin showed nearly bactericidal activity. Metronidazole proved to be the most active antimicrobial agent.

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Year:  2012        PMID： 22430962      PMCID： PMC3370753          DOI： 10.1128/AAC.00099-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  28 in total

1.  In vitro activities of gatifloxacin, two other quinolones, and five nonquinolone antimicrobials against obligately anaerobic bacteria.

Authors:  R Schaumann; G Ackermann; B Pless; M C Claros; A C Rodloff
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

2.  In vitro activities of fourteen antimicrobial agents against obligately anaerobic bacteria.

Authors:  R Schaumann; G Ackermann; B Pless; M C Claros; E J Goldstein; A C Rodloff
Journal:  Int J Antimicrob Agents       Date:  2000-11       Impact factor: 5.283

Review 3.  Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: kill curves versus MIC.

Authors:  Markus Mueller; Amparo de la Peña; Hartmut Derendorf
Journal:  Antimicrob Agents Chemother       Date:  2004-02       Impact factor: 5.191

4.  Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience.

Authors:  E Nagy; E Urbán; Carl Erik Nord
Journal:  Clin Microbiol Infect       Date:  2011-03       Impact factor: 8.067

5.  Comparison of the pharmacokinetics of metronidazole in healthy female volunteers following either a single oral or intravenous dose.

Authors:  G W Houghton; P S Thorne; J Smith; R Templeton; J Collier
Journal:  Br J Clin Pharmacol       Date:  1979-10       Impact factor: 4.335

6.  High prevalence of resistance to clindamycin in Bacteroides fragilis group isolates.

Authors:  J Oteo; B Aracil; J I Alós; J L Gómez-Garcés
Journal:  J Antimicrob Chemother       Date:  2000-05       Impact factor: 5.790

7.  Steady-state plasma and intrapulmonary concentrations of cefepime administered in continuous infusion in critically ill patients with severe nosocomial pneumonia.

Authors:  Emmanuel Boselli; Dominique Breilh; Frédéric Duflo; Marie-Claude Saux; Richard Debon; Dominique Chassard; Bernard Allaouchiche
Journal:  Crit Care Med       Date:  2003-08       Impact factor: 7.598

8.  National survey on the susceptibility of Bacteroides Fragilis Group: report and analysis of trends for 1997-2000.

Authors:  D R Snydman; N V Jacobus; L A McDermott; R Ruthazer; E J C Goldstein; S M Finegold; L J Harrell; D W Hecht; S G Jenkins; C Pierson; R Venezia; J Rihs; S L Gorbach
Journal:  Clin Infect Dis       Date:  2002-09-01       Impact factor: 9.079

9.  Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe.

Authors:  M Hedberg; C E Nord
Journal:  Clin Microbiol Infect       Date:  2003-06       Impact factor: 8.067

10.  Emergence of fluoroquinolone resistance among Bacteroides species.

Authors:  Yoav Golan; Laura A McDermott; Nilda V Jacobus; Ellie J C Goldstein; Sydney Finegold; Lizzie J Harrell; David W Hecht; Stephen G Jenkins; C Pierson; Richard Venezia; Jack Rihs; Paul Iannini; Sherwood L Gorbach; David R Snydman
Journal:  J Antimicrob Chemother       Date:  2003-07-15       Impact factor: 5.790
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  1 in total

Review 1.  Pelvic surgical site infections in gynecologic surgery.

Authors:  Mark P Lachiewicz; Laura J Moulton; Oluwatosin Jaiyeoba
Journal:  Infect Dis Obstet Gynecol       Date:  2015-02-18
  1 in total

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