OBJECTIVE: To investigate whether 24-hour urinary sodium excretion could be an indicator of the effectiveness of salt supplementation in children with postural orthostatic tachycardia syndrome (POTS). STUDY DESIGN: The patient group comprised 30 children with POTS, and the control group comprised 10 healthy children. Serum sodium and 24-hour urinary sodium excretion were measured in all children, and the relationship between 24-hour urinary sodium and symptom severity was analyzed in the 30 patients. At 1 month after initiation of salt supplementation, the receiver operating characteristic curve was used to explore the probability of correctly discriminating responders to salt supplementation from nonresponders using 24-hour urinary sodium excretion as an indicator. RESULTS: Patients with POTS had lower 24-hour urinary sodium excretion than controls (P = .022). Symptom severity was negatively correlated with 24-hour urinary sodium excretion (OR, -0.754; P = .000). The receiver operating characteristic curve demonstrated a sensitivity of 76.9% and specificity of 93% for correct prediction of responders and nonresponders to salt supplementation when a 24-hour urinary sodium excretion of 124 mmol/24 hours was used as the cutoff value. CONCLUSION: Our results indicate that 24-hour sodium excretion of <124 mmol/24 hours is an indicator of the effectiveness of salt supplementation in children and adolescents with POTS.
OBJECTIVE: To investigate whether 24-hour urinary sodium excretion could be an indicator of the effectiveness of salt supplementation in children with postural orthostatic tachycardia syndrome (POTS). STUDY DESIGN: The patient group comprised 30 children with POTS, and the control group comprised 10 healthy children. Serum sodium and 24-hour urinary sodium excretion were measured in all children, and the relationship between 24-hour urinary sodium and symptom severity was analyzed in the 30 patients. At 1 month after initiation of salt supplementation, the receiver operating characteristic curve was used to explore the probability of correctly discriminating responders to salt supplementation from nonresponders using 24-hour urinary sodium excretion as an indicator. RESULTS:Patients with POTS had lower 24-hour urinary sodium excretion than controls (P = .022). Symptom severity was negatively correlated with 24-hour urinary sodium excretion (OR, -0.754; P = .000). The receiver operating characteristic curve demonstrated a sensitivity of 76.9% and specificity of 93% for correct prediction of responders and nonresponders to salt supplementation when a 24-hour urinary sodium excretion of 124 mmol/24 hours was used as the cutoff value. CONCLUSION: Our results indicate that 24-hour sodium excretion of <124 mmol/24 hours is an indicator of the effectiveness of salt supplementation in children and adolescents with POTS.
Authors: Julian M Stewart; Jeffrey R Boris; Gisela Chelimsky; Phillip R Fischer; John E Fortunato; Blair P Grubb; Geoffrey L Heyer; Imad T Jarjour; Marvin S Medow; Mohammed T Numan; Paolo T Pianosi; Wolfgang Singer; Sally Tarbell; Thomas C Chelimsky Journal: Pediatrics Date: 2017-12-08 Impact factor: 7.124
Authors: Rocío A Figueroa; Amy C Arnold; Victor C Nwazue; Luis E Okamoto; Sachin Y Paranjape; Bonnie K Black; Andre Diedrich; David Robertson; Italo Biaggioni; Satish R Raj; Alfredo Gamboa Journal: J Appl Physiol (1985) Date: 2014-07-24
Authors: Emily M Garland; Alfredo Gamboa; Victor C Nwazue; Jorge E Celedonio; Sachin Y Paranjape; Bonnie K Black; Luis E Okamoto; Cyndya A Shibao; Italo Biaggioni; David Robertson; André Diedrich; William D Dupont; Satish R Raj Journal: J Am Coll Cardiol Date: 2021-05-04 Impact factor: 24.094