Literature DB >> 22422962

Comment on "Widespread RNA and DNA sequence differences in the human transcriptome".

Claudia L Kleinman1, Jacek Majewski.   

Abstract

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported large numbers of differences between DNA and messenger RNA in human cells, indicating unprecedented levels of RNA editing, and including sequence changes not produced by any of the known RNA editing mechanisms. However, common sources of systematic errors in high-throughput sequencing technology, which were not properly accounted for in this study, explain most of the claimed differences.

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Year:  2012        PMID： 22422962     DOI： 10.1126/science.1209658

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  99 in total

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Journal:  Am J Hum Genet       Date:  2013-09-26       Impact factor: 11.025

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9.  Assessing the validity and reproducibility of genome-scale predictions.

Authors:  Lauren A Sugden; Michael R Tackett; Yiannis A Savva; William A Thompson; Charles E Lawrence
Journal:  Bioinformatics       Date:  2013-09-17       Impact factor: 6.937

10.  Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer.

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