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Literature DB >> 22421206

New generation QuIC assays for prion seeding activity.

Christina D Orrù¹, Jason M Wilham, Sarah Vascellari, Andrew G Hughson, Byron Caughey.

Abstract

The ability of abnormal TSE-associated forms of PrP to seed the formation of amyloid fibrils from recombinant PrP(Sen) has served as the basis for several relatively rapid and highly sensitive tests for prion diseases. These tests include rPrP-PMCA (rPMCA), standard quaking-induced conversion (S-QuIC), amyloid seeding assay (ASA), real-time QuIC (RT-QuIC) and enhanced QuIC (eQuIC). Here, we summarize recent improvements in the RT-QuIC-based assays that enhance the practicality, sensitivity and quantitative attributes of assays QuIC and promote the detection of prion seeding activity in dilute, inhibitor-laden fluids such as blood plasma.

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Year: 2012 PMID： 22421206 PMCID： PMC7082091 DOI： 10.4161/pri.19430

Source DB: PubMed Journal: Prion ISSN： 1933-6896 Impact factor: 3.931

43 in total

1. Detection of pathologic prion protein in the olfactory epithelium in sporadic Creutzfeldt-Jakob disease.

Authors: Gianluigi Zanusso; Sergio Ferrari; Franco Cardone; Paolo Zampieri; Matteo Gelati; Michele Fiorini; Alessia Farinazzo; Marina Gardiman; Tiziana Cavallaro; Marina Bentivoglio; Pier Giorgio Righetti; Maurizio Pocchiari; Nicola Rizzuto; Salvatore Monaco
Journal: N Engl J Med Date: 2003-02-20 Impact factor: 91.245

2. Presymptomatic detection of prions in blood.

Authors: Paula Saá; Joaquín Castilla; Claudio Soto
Journal: Science Date: 2006-07-07 Impact factor: 47.728

3. Prions are secreted in milk from clinically normal scrapie-exposed sheep.

Authors: B C Maddison; C A Baker; H C Rees; L A Terry; L Thorne; S J Bellworthy; G C Whitelam; K C Gough
Journal: J Virol Date: 2009-06-03 Impact factor: 5.103

Review 4. Prion seeded conversion and amplification assays.

Authors: Christina D Orrú; Byron Caughey
Journal: Top Curr Chem Date: 2011

5. Real-time quaking-induced conversion: a highly sensitive assay for prion detection.

Authors: Ryuichiro Atarashi; Kazunori Sano; Katsuya Satoh; Noriyuki Nishida
Journal: Prion Date: 2011-07-01 Impact factor: 3.931

6. Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays.

Authors: Jason M Wilham; Christina D Orrú; Richard A Bessen; Ryuichiro Atarashi; Kazunori Sano; Brent Race; Kimberly D Meade-White; Lara M Taubner; Andrew Timmes; Byron Caughey
Journal: PLoS Pathog Date: 2010-12-02 Impact factor: 6.823

7. Prion (PrPSc)-specific epitope defined by a monoclonal antibody.

Authors: C Korth; B Stierli; P Streit; M Moser; O Schaller; R Fischer; W Schulz-Schaeffer; H Kretzschmar; A Raeber; U Braun; F Ehrensperger; S Hornemann; R Glockshuber; R Riek; M Billeter; K Wüthrich; B Oesch
Journal: Nature Date: 1997-11-06 Impact factor: 49.962

8. Efficient in vitro amplification of chronic wasting disease PrPRES.

Authors: Timothy D Kurt; Matthew R Perrott; Carol J Wilusz; Jeffrey Wilusz; Surachai Supattapone; Glenn C Telling; Mark D Zabel; Edward A Hoover
Journal: J Virol Date: 2007-06-06 Impact factor: 5.103

9. Detection of PrPsc in blood from sheep infected with the scrapie and bovine spongiform encephalopathy agents.

Authors: L A Terry; L Howells; J Hawthorn; J C Edwards; S J Moore; S J Bellworthy; H Simmons; S Lizano; L Estey; V Leathers; S J Everest
Journal: J Virol Date: 2009-09-09 Impact factor: 5.103

10. Protease-sensitive synthetic prions.

Authors: David W Colby; Rachel Wain; Ilia V Baskakov; Giuseppe Legname; Christina G Palmer; Hoang-Oanh B Nguyen; Azucena Lemus; Fred E Cohen; Stephen J DeArmond; Stanley B Prusiner
Journal: PLoS Pathog Date: 2010-01-22 Impact factor: 6.823

50 in total

Review 1. Prions and the potential transmissibility of protein misfolding diseases.

Authors: Allison Kraus; Bradley R Groveman; Byron Caughey
Journal: Annu Rev Microbiol Date: 2013-06-28 Impact factor: 15.500

2. Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions.

Authors: Kristen A Davenport; Clare E Hoover; Nathaniel D Denkers; Candace K Mathiason; Edward A Hoover
Journal: J Clin Microbiol Date: 2018-08-27 Impact factor: 5.948

3. The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases.

Authors: Matthias Schmitz; Maria Cramm; Franc Llorens; Dominik Müller-Cramm; Steven Collins; Ryuichiro Atarashi; Katsuya Satoh; Christina D Orrù; Bradley R Groveman; Saima Zafar; Walter J Schulz-Schaeffer; Byron Caughey; Inga Zerr
Journal: Nat Protoc Date: 2016-10-13 Impact factor: 13.491

Review 4. Molecular and Clinical Aspects of Protein Aggregation Assays in Neurodegenerative Diseases.

Authors: Anna Villar-Piqué; Matthias Schmitz; Niccolò Candelise; Salvador Ventura; Franc Llorens; Inga Zerr
Journal: Mol Neurobiol Date: 2018-02-10 Impact factor: 5.590

5. Diagnostic and prognostic value of human prion detection in cerebrospinal fluid.

Authors: Aaron Foutz; Brian S Appleby; Clive Hamlin; Xiaoqin Liu; Sheng Yang; Yvonne Cohen; Wei Chen; Janis Blevins; Cameron Fausett; Han Wang; Pierluigi Gambetti; Shulin Zhang; Andrew Hughson; Curtis Tatsuoka; Lawrence B Schonberger; Mark L Cohen; Byron Caughey; Jiri G Safar
Journal: Ann Neurol Date: 2017-01 Impact factor: 10.422

6. Susceptibility of domestic cats to chronic wasting disease.

Authors: Candace K Mathiason; Amy V Nalls; Davis M Seelig; Susan L Kraft; Kevin Carnes; Kelly R Anderson; Jeanette Hayes-Klug; Edward A Hoover
Journal: J Virol Date: 2012-12-12 Impact factor: 5.103

Review 7. Neuroradiology of human prion diseases, diagnosis and differential diagnosis.

Authors: Simona Gaudino; Emma Gangemi; Raffaella Colantonio; Annibale Botto; Emanuela Ruberto; Rosalinda Calandrelli; Matia Martucci; Maria Gabriella Vita; Carlo Masullo; Alfonso Cerase; Cesare Colosimo
Journal: Radiol Med Date: 2017-01-21 Impact factor: 3.469