PURPOSE: Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare carcinoma with distinct characteristics. No standard treatment has been established. This retrospective study was designed to investigate the clinical and pathological characteristics, diagnosis, treatment, and prognosis of esophageal BSCC. METHODS: Clinical data were retrospectively analyzed from 26 patients with pathologically confirmed esophageal BSCC who underwent transthoracic esophagectomy with lymphadenectomy between January 1995 and June 2010 at the Cancer Hospital of Shantou University Medical College. Clinicopathologic data between BSCC patients and different histologic grades of esophageal squamous cell carcinoma (ESCC) patients were statistically compared by means of the χ(2) test or Fisher's exact test. The Kaplan-Meier and log-rank methods were used to estimate and compare survival rates. RESULTS: Microscopically, BSCC was characterized by a nesting, lobular, or trabecular arrangement of small crowded cells with scant cytoplasm. None of the histologic specimens taken at preoperative esophagoscopy were diagnosed as BSCC. The median survival time (MST) of the 26 patients was 29.0 months (95% confidence interval, 9.0-49.0), and the 1-, 3-, and 5-year overall survival rates were 73.1, 42.7, and 36.6%, respectively. The MST for BSCC patients was significantly lower than that of well-differentiated SCC patients (P = 0.024), but there were no significant differences between the MST for BSCC patients and that of moderately or poorly differentiated SCC patients (P > 0.05). CONCLUSIONS: BSCC of the esophagus is a rare but distinctive disease and is prone to be misdiagnosed by endoscopic biopsy. The prognosis is poorer than well-differentiated SCC, but similar to moderately or poorly differentiated SCC.
PURPOSE: Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare carcinoma with distinct characteristics. No standard treatment has been established. This retrospective study was designed to investigate the clinical and pathological characteristics, diagnosis, treatment, and prognosis of esophageal BSCC. METHODS: Clinical data were retrospectively analyzed from 26 patients with pathologically confirmed esophageal BSCC who underwent transthoracic esophagectomy with lymphadenectomy between January 1995 and June 2010 at the Cancer Hospital of Shantou University Medical College. Clinicopathologic data between BSCC patients and different histologic grades of esophageal squamous cell carcinoma (ESCC) patients were statistically compared by means of the χ(2) test or Fisher's exact test. The Kaplan-Meier and log-rank methods were used to estimate and compare survival rates. RESULTS: Microscopically, BSCC was characterized by a nesting, lobular, or trabecular arrangement of small crowded cells with scant cytoplasm. None of the histologic specimens taken at preoperative esophagoscopy were diagnosed as BSCC. The median survival time (MST) of the 26 patients was 29.0 months (95% confidence interval, 9.0-49.0), and the 1-, 3-, and 5-year overall survival rates were 73.1, 42.7, and 36.6%, respectively. The MST for BSCC patients was significantly lower than that of well-differentiated SCCpatients (P = 0.024), but there were no significant differences between the MST for BSCC patients and that of moderately or poorly differentiated SCCpatients (P > 0.05). CONCLUSIONS: BSCC of the esophagus is a rare but distinctive disease and is prone to be misdiagnosed by endoscopic biopsy. The prognosis is poorer than well-differentiated SCC, but similar to moderately or poorly differentiated SCC.
Authors: Inga-Marie Schaefer; Christina Enders; Andreas Polten; Florian Haller; Andreas M J Frölich; Silke Cameron; Philipp Schüler; Peter Schweiger; Bastian Gunawan; Alexander Beham; László Füzesi Journal: Am J Clin Pathol Date: 2011-04 Impact factor: 2.493
Authors: Y Kobayashi; Y Nakanishi; H Taniguchi; S Sekine; H Igaki; Y Tachimori; H Kato; H Matsubara; S Okazumi; T Shimoda Journal: Dis Esophagus Date: 2008-10-10 Impact factor: 3.429
Authors: Andrew M Bellizzi; Randall L Woodford; Christopher A Moskaluk; David R Jones; Benjamin D Kozower; Edward B Stelow Journal: Am J Surg Pathol Date: 2009-11 Impact factor: 6.394
Authors: H Noguchi; Y Naomoto; M Haisa; T Yamatsuji; K Shigemitsu; Y Shirakawa; M Kataoka; T Ohkawa; T Nobuhisa; M Kobayashi; M Gunduz; N Tanaka Journal: Dis Esophagus Date: 2003 Impact factor: 3.429
Authors: Li C Wang; Lei Wang; Sabrina Kwauk; Jennifer A Woo; Li Q Wu; Hong Zhu; Li Z Zhan; Na L Sun; Lei Zhang Journal: J Cardiothorac Surg Date: 2011-01-26 Impact factor: 1.637
Authors: Yukie Sato-Kuwabara; José Humberto T G Fregnani; Juliano Jampietro; Katia Cândido Carvalho; Carolina Parucce Franco; Wilson Luís da Costa; Felipe J F Coimbra; Fernando Augusto Soares Journal: Tumour Biol Date: 2015-12-09