Literature DB >> 22418775

Hydrocolloid-based nutraceutical delivery systems.

Srinivas Janaswamy1, Susanne R Youngren.   

Abstract

Nutraceuticals are important due to their inherent health benefits. However, utilization and consumption are limited by their poor water solubility and instability at normal processing and storage conditions. Herein, we propose an elegant and novel approach for the delivery of nutraceuticals in their active form using hydrocolloid matrices that are inexpensive and non-toxic with generally recognized as safe (GRAS) status. Iota-carrageenan and curcumin have been chosen as models of hydrocolloid and nutraceutical compounds, respectively. The iota-carrageenan network maintains a stable organization after encapsulating curcumin molecules, protects them from melting and then releases them in a sustained manner. These findings lay a strong foundation for developing value-added functional and medicinal foods.

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Year:  2012        PMID: 22418775      PMCID: PMC3343193          DOI: 10.1039/c2fo10281a

Source DB:  PubMed          Journal:  Food Funct        ISSN: 2042-6496            Impact factor:   5.396


  14 in total

1.  Effect of calcium ions on the organization of iota-carrageenan helices: an X-ray investigation.

Authors:  Srinivas Janaswamy; Rengaswami Chandrasekaran
Journal:  Carbohydr Res       Date:  2002-03-15       Impact factor: 2.104

2.  Three-dimensional structure of the sodium salt of iota-carrageenan.

Authors:  S Janaswamy; R Chandrasekaran
Journal:  Carbohydr Res       Date:  2001-10-08       Impact factor: 2.104

Review 3.  Challenges for the oral delivery of macromolecules.

Authors:  Michael Goldberg; Isabel Gomez-Orellana
Journal:  Nat Rev Drug Discov       Date:  2003-04       Impact factor: 84.694

Review 4.  Designing materials for biology and medicine.

Authors:  Robert Langer; David A Tirrell
Journal:  Nature       Date:  2004-04-01       Impact factor: 49.962

Review 5.  New methods of drug delivery.

Authors:  R Langer
Journal:  Science       Date:  1990-09-28       Impact factor: 47.728

Review 6.  Novel applications of liposomes.

Authors:  D D Lasic
Journal:  Trends Biotechnol       Date:  1998-07       Impact factor: 19.536

Review 7.  Molecular architecture of polysaccharide helices in oriented fibers.

Authors:  R Chandrasekaran
Journal:  Adv Carbohydr Chem Biochem       Date:  1997       Impact factor: 12.200

8.  In vivo release of plasmid DNA from composites of oligo(poly(ethylene glycol)fumarate) and cationized gelatin microspheres.

Authors:  F Kurtis Kasper; Toshihiro Kushibiki; Yu Kimura; Antonios G Mikos; Yasuhiko Tabata
Journal:  J Control Release       Date:  2005-10-20       Impact factor: 9.776

Review 9.  Curcumin: from ancient medicine to current clinical trials.

Authors:  H Hatcher; R Planalp; J Cho; F M Torti; S V Torti
Journal:  Cell Mol Life Sci       Date:  2008-06       Impact factor: 9.261

10.  Protection of bifidobacteria encapsulated in polysaccharide-protein gel beads against gastric juice and bile.

Authors:  Daniel Guérin; Jean-Christophe Vuillemard; Muriel Subirade
Journal:  J Food Prot       Date:  2003-11       Impact factor: 2.077

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  3 in total

1.  Organized polysaccharide fibers as stable drug carriers.

Authors:  Srinivas Janaswamy; Kristin L Gill; Osvaldo H Campanella; Rodolfo Pinal
Journal:  Carbohydr Polym       Date:  2013-01-11       Impact factor: 9.381

2.  Hydrocolloid-based nutraceutical delivery systems: Effect of counter-ions on the encapsulation and release.

Authors:  Patrick J Polowsky; Srinivas Janaswamy
Journal:  Food Hydrocoll       Date:  2015-01-01       Impact factor: 9.147

3.  Carriers Based on Zein-Dextran Sulfate Sodium Binary Complex for the Sustained Delivery of Quercetin.

Authors:  Tian-Xing Wang; Xiao-Xi Li; Ling Chen; Lin Li; Srinivas Janaswamy
Journal:  Front Chem       Date:  2020-09-30       Impact factor: 5.221

  3 in total

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