BACKGROUND: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants. OBJECTIVE: To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise. METHODS: We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area. RESULTS: Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein-1, and interleukin-6, but did not change coagulation tendency or heart rate variability. CONCLUSION: Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.
BACKGROUND: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants. OBJECTIVE: To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise. METHODS: We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area. RESULTS: Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein-1, and interleukin-6, but did not change coagulation tendency or heart rate variability. CONCLUSION: Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.
Authors: D C Nieman; S L Nehlsen-Cannarella; K M Donohue; D B Chritton; B L Haddock; R W Stout; J W Lee Journal: Med Sci Sports Exerc Date: 1991-05 Impact factor: 5.411
Authors: J R Stratton; W L Chandler; R S Schwartz; M D Cerqueira; W C Levy; S E Kahn; V G Larson; K C Cain; J C Beard; I B Abrass Journal: Circulation Date: 1991-05 Impact factor: 29.690
Authors: Nicholas L Mills; Alexander E Finlayson; Manuel C Gonzalez; Håkan Törnqvist; Stefan Barath; Elen Vink; Colin Goudie; Jeremy P Langrish; Stefan Söderberg; Nicholas A Boon; Keith A A Fox; Ken Donaldson; Thomas Sandström; Anders Blomberg; David E Newby Journal: Heart Date: 2010-10-20 Impact factor: 5.994
Authors: Cristiane Maria Galvão Barbosa; Mário Terra-Filho; André Luis Pereira de Albuquerque; Dante Di Giorgi; Cesar Grupi; Carlos Eduardo Negrão; Maria Urbana Pinto Brandão Rondon; Daniel Godoy Martinez; Tânia Marcourakis; Fabiana Almeida dos Santos; Alfésio Luís Ferreira Braga; Dirce Maria Trevisan Zanetta; Ubiratan de Paula Santos Journal: PLoS One Date: 2012-09-27 Impact factor: 3.240