OBJECTIVE: Exposure to air pollution is associated with increases in cardiovascular morbidity and mortality. This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease. DESIGN AND SETTING: Double-blind randomised crossover studies in a university teaching hospital. PATIENTS: 32 healthy non-smoking volunteers and 20 patients with prior myocardial infarction. INTERVENTIONS: All 52 subjects were exposed for 1 h to dilute diesel exhaust (particle concentration 300 μg/m³) or filtered air. MAIN OUTCOME MEASURES: Heart rhythm and heart rate variability were monitored during and for 24 h after the exposure using continuous ambulatory electrocardiography and assessed using standard time and frequency domain analysis. RESULTS: No significant arrhythmias occurred during or following exposures. Patients with coronary heart disease had reduced autonomic function in comparison to healthy volunteers, with reduced standard deviations of the NN interval (SDNN, p < 0.001) and triangular index (p < 0.001). Diesel exhaust did not affect heart rate variability compared with filtered air (p > 0.05 for all) in healthy volunteers (SDNN 101 ± 6 vs 91 ± 6, triangular index 20 ± 1 vs 21 ± 1) or patients with coronary heart disease (SDNN 47 ± 5 vs 38 ± 4, triangular index 8 ± 1 vs 7 ± 1). CONCLUSIONS: Brief exposure to dilute diesel exhaust does not alter heart rhythm or heart rate variability in healthy volunteers or well-treated patients with stable coronary heart disease. Autonomic dysfunction does not appear to be a dominant mechanism that can explain the observed excess in cardiovascular events following exposure to combustion-derived air pollution.
OBJECTIVE: Exposure to air pollution is associated with increases in cardiovascular morbidity and mortality. This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease. DESIGN AND SETTING: Double-blind randomised crossover studies in a university teaching hospital. PATIENTS: 32 healthy non-smoking volunteers and 20 patients with prior myocardial infarction. INTERVENTIONS: All 52 subjects were exposed for 1 h to dilute diesel exhaust (particle concentration 300 μg/m³) or filtered air. MAIN OUTCOME MEASURES: Heart rhythm and heart rate variability were monitored during and for 24 h after the exposure using continuous ambulatory electrocardiography and assessed using standard time and frequency domain analysis. RESULTS: No significant arrhythmias occurred during or following exposures. Patients with coronary heart disease had reduced autonomic function in comparison to healthy volunteers, with reduced standard deviations of the NN interval (SDNN, p < 0.001) and triangular index (p < 0.001). Diesel exhaust did not affect heart rate variability compared with filtered air (p > 0.05 for all) in healthy volunteers (SDNN 101 ± 6 vs 91 ± 6, triangular index 20 ± 1 vs 21 ± 1) or patients with coronary heart disease (SDNN 47 ± 5 vs 38 ± 4, triangular index 8 ± 1 vs 7 ± 1). CONCLUSIONS: Brief exposure to dilute diesel exhaust does not alter heart rhythm or heart rate variability in healthy volunteers or well-treated patients with stable coronary heart disease. Autonomic dysfunction does not appear to be a dominant mechanism that can explain the observed excess in cardiovascular events following exposure to combustion-derived air pollution.
Authors: Alex P Carll; Mehdi S Hazari; Christina M Perez; Quentin Todd Krantz; Charly J King; Darrell W Winsett; Daniel L Costa; Aimen K Farraj Journal: Toxicol Sci Date: 2012-04-26 Impact factor: 4.849
Authors: Alex P Carll; Najwa Haykal-Coates; Darrell W Winsett; Mehdi S Hazari; Allen D Ledbetter; Judy H Richards; Wayne E Cascio; Daniel L Costa; Aimen K Farraj Journal: Inhal Toxicol Date: 2015-02 Impact factor: 2.724
Authors: Bernd Niemann; Susanne Rohrbach; Mark R Miller; David E Newby; Valentin Fuster; Jason C Kovacic Journal: J Am Coll Cardiol Date: 2017-07-11 Impact factor: 24.094
Authors: Mehdi S Hazari; Najwa Haykal-Coates; Darrell W Winsett; Q Todd Krantz; Charly King; Daniel L Costa; Aimen K Farraj Journal: Environ Health Perspect Date: 2011-03-04 Impact factor: 9.031