Literature DB >> 22417173

Systems pharmacology of complex diseases.

Jens Hansen1, Shan Zhao, Ravi Iyengar.   

Abstract

Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
© 2012 New York Academy of Sciences.

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Year:  2011        PMID： 22417173      PMCID： PMC3620720          DOI： 10.1111/j.1749-6632.2011.06382.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  9 in total

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6.  Network analysis of FDA approved drugs and their targets.

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Review 7.  Network analyses in systems pharmacology.

Authors:  Seth I Berger; Ravi Iyengar
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Authors:  F Kaplan; K Al-Majali; D J Betteridge
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9.  Mining Alzheimer disease relevant proteins from integrated protein interactome data.

Authors:  Jake Yue Chen; Changyu Shen; Andrey Y Sivachenko
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  9 in total
  10 in total

Review 1.  Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders.

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Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-03-23       Impact factor: 13.820

2.  Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration.

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3.  Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension.

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6.  Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies.

Authors:  Timothy S Kern; Yunpeng Du; Jie Tang; Chieh Allen Lee; Haitao Liu; Alyssa Dreffs; Henri Leinonen; David A Antonetti; Krzysztof Palczewski
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7.  Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Authors:  Yu Chen; Grazyna Palczewska; Ikuo Masuho; Songqi Gao; Hui Jin; Zhiqian Dong; Linn Gieser; Matthew J Brooks; Philip D Kiser; Timothy S Kern; Kirill A Martemyanov; Anand Swaroop; Krzysztof Palczewski
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Review 8.  Personalizing health care: feasibility and future implications.

Authors:  Brian Godman; Alexander E Finlayson; Parneet K Cheema; Eva Zebedin-Brandl; Inaki Gutiérrez-Ibarluzea; Jan Jones; Rickard E Malmström; Elina Asola; Christoph Baumgärtel; Marion Bennie; Iain Bishop; Anna Bucsics; Stephen Campbell; Eduardo Diogene; Alessandra Ferrario; Jurij Fürst; Kristina Garuoliene; Miguel Gomes; Katharine Harris; Alan Haycox; Harald Herholz; Krystyna Hviding; Saira Jan; Marija Kalaba; Christina Kvalheim; Ott Laius; Sven-Ake Lööv; Kamila Malinowska; Andrew Martin; Laura McCullagh; Fredrik Nilsson; Ken Paterson; Ulrich Schwabe; Gisbert Selke; Catherine Sermet; Steven Simoens; Dominik Tomek; Vera Vlahovic-Palcevski; Luka Voncina; Magdalena Wladysiuk; Menno van Woerkom; Durhane Wong-Rieger; Corrine Zara; Raghib Ali; Lars L Gustafsson
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Review 10.  Towards structural systems pharmacology to study complex diseases and personalized medicine.

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  10 in total

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