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Literature DB >> 22417133

Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.

Daniel J Callahan¹, Wenge Liu, Xinghai Li, Matthew R Dreher, Wafa Hassouneh, Minkyu Kim, Piotr Marszalek, Ashutosh Chilkoti.

Abstract

To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn(2+) and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2012 PMID： 22417133 PMCID： PMC3474318 DOI： 10.1021/nl300630c

Source DB: PubMed Journal: Nano Lett ISSN： 1530-6984 Impact factor: 11.189

39 in total

1. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc.

Authors: P Trumbo; A A Yates; S Schlicker; M Poos
Journal: J Am Diet Assoc Date: 2001-03

2. Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system.

Authors: Dan E Meyer; Ashutosh Chilkoti
Journal: Biomacromolecules Date: 2002 Mar-Apr Impact factor: 6.988

Review 3. Exploitation of intracellular pH gradients in the cellular delivery of macromolecules.

Authors: Aravind Asokan; Moo J Cho
Journal: J Pharm Sci Date: 2002-04 Impact factor: 3.534

4. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change.

Authors: Younsoo Bae; Shigeto Fukushima; Atsushi Harada; Kazunori Kataoka
Journal: Angew Chem Int Ed Engl Date: 2003-10-06 Impact factor: 15.336

5. pH-sensitive, plasma-stable liposomes with relatively prolonged residence in circulation.

Authors: D Liu; L Huang
Journal: Biochim Biophys Acta Date: 1990-03

6. Development of the polymer micelle carrier system for doxorubicin.

Authors: T Nakanishi; S Fukushima; K Okamoto; M Suzuki; Y Matsumura; M Yokoyama; T Okano; Y Sakurai; K Kataoka
Journal: J Control Release Date: 2001-07-06 Impact factor: 9.776

7. Polymeric micelle for tumor pH and folate-mediated targeting.

Authors: Eun Seong Lee; Kun Na; You Han Bae
Journal: J Control Release Date: 2003-08-28 Impact factor: 9.776

8. Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization.

Authors: Eun Seong Lee; Hyun Joon Shin; Kun Na; You Han Bae
Journal: J Control Release Date: 2003-07-31 Impact factor: 9.776

9. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery.

Authors: Anupama Potineni; David M Lynn; Robert Langer; Mansoor M Amiji
Journal: J Control Release Date: 2003-01-17 Impact factor: 9.776

Review 10. An overview of the structures of protein-DNA complexes.

Authors: N M Luscombe; S E Austin; H M Berman; J M Thornton
Journal: Genome Biol Date: 2000-06-09 Impact factor: 13.583

23 in total

1. Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices.

Authors: Tianzhi Luo; Michael A David; Lucas C Dunshee; Rebecca A Scott; Morgan A Urello; Christopher Price; Kristi L Kiick
Journal: Biomacromolecules Date: 2017-08-01 Impact factor: 6.988

Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.

1. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc.

2. Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system.

Review 3. Exploitation of intracellular pH gradients in the cellular delivery of macromolecules.

4. Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change.

5. pH-sensitive, plasma-stable liposomes with relatively prolonged residence in circulation.

6. Development of the polymer micelle carrier system for doxorubicin.

7. Polymeric micelle for tumor pH and folate-mediated targeting.

8. Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization.

9. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery.

Review 10. An overview of the structures of protein-DNA complexes.

1. Thermoresponsive Elastin-b-Collagen-Like Peptide Bioconjugate Nanovesicles for Targeted Drug Delivery to Collagen-Containing Matrices.

2. A unified model for de novo design of elastin-like polypeptides with tunable inverse transition temperatures.

Review 3. Controlled release from recombinant polymers.

4. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles.

5. Temperature-triggered phase separation of a hydrophilic resilin-like polypeptide.

6. A thermo-responsive protein treatment for dry eyes.

7. Engineering the Architecture of Elastin-Like Polypeptides: From Unimers to Hierarchical Self-Assembly.

8. Calcium binding peptide motifs from calmodulin confer divalent ion selectivity to elastin-like polypeptides.

Review 9. Recent trends in protein and peptide-based biomaterials for advanced drug delivery.

10. Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry.