| Literature DB >> 22416243 |
Sophie Octavia1, Vitali Sintchenko, Gwendolyn L Gilbert, Andrew Lawrence, Anthony D Keil, Geoff Hogg, Ruiting Lan.
Abstract
Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.Entities:
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Year: 2012 PMID： 22416243 DOI： 10.1093/infdis/jis178
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226