BACKGROUND: The objective of this study was to examine the relation between dietary fats and semen quality parameters. METHODS: Data from 99 men with complete dietary and semen quality data were analyzed. Fatty acid levels in sperm and seminal plasma were measured using gas chromatography in a subgroup of men (n = 23). Linear regression was used to determine associations while adjusting for potential confounders. RESULTS: Men were primarily Caucasian (89%) with a mean (SD) age of 36.4 (5.3) years; 71% were overweight or obese; and 67% were never smokers. Higher total fat intake was negatively related to total sperm count and concentration. Men in the highest third of total fat intake had 43% (95% confidence interval (CI): 62-14%) lower total sperm count and 38% (95% CI: 58-10%) lower sperm concentration than men in the lowest third (P(trend) = 0.01). This association was driven by intake of saturated fats. Levels of saturated fatty acids in sperm were also negatively related to sperm concentration (r= -0.53), but saturated fat intake was unrelated to sperm levels (r = 0.09). Higher intake of omega-3 polyunsaturated fats was related to a more favorable sperm morphology. Men in the highest third of omega-3 fatty acids had 1.9% (0.4-3.5%) higher normal morphology than men in the lowest third (P(trend) = 0.02). CONCLUSIONS: In this preliminary cross-sectional study, high intake of saturated fats was negatively related to sperm concentration whereas higher intake of omega-3 fats was positively related to sperm morphology. Further, studies with larger samples are now required to confirm these findings.
BACKGROUND: The objective of this study was to examine the relation between dietary fats and semen quality parameters. METHODS: Data from 99 men with complete dietary and semen quality data were analyzed. Fatty acid levels in sperm and seminal plasma were measured using gas chromatography in a subgroup of men (n = 23). Linear regression was used to determine associations while adjusting for potential confounders. RESULTS:Men were primarily Caucasian (89%) with a mean (SD) age of 36.4 (5.3) years; 71% were overweight or obese; and 67% were never smokers. Higher total fat intake was negatively related to total sperm count and concentration. Men in the highest third of total fat intake had 43% (95% confidence interval (CI): 62-14%) lower total sperm count and 38% (95% CI: 58-10%) lower sperm concentration than men in the lowest third (P(trend) = 0.01). This association was driven by intake of saturated fats. Levels of saturated fatty acids in sperm were also negatively related to sperm concentration (r= -0.53), but saturated fat intake was unrelated to sperm levels (r = 0.09). Higher intake of omega-3 polyunsaturated fats was related to a more favorable sperm morphology. Men in the highest third of omega-3 fatty acids had 1.9% (0.4-3.5%) higher normal morphology than men in the lowest third (P(trend) = 0.02). CONCLUSIONS: In this preliminary cross-sectional study, high intake of saturated fats was negatively related to sperm concentration whereas higher intake of omega-3fats was positively related to sperm morphology. Further, studies with larger samples are now required to confirm these findings.
Authors: K Zhang; M Kniazeva; M Han; W Li; Z Yu; Z Yang; Y Li; M L Metzker; R Allikmets; D J Zack; L E Kakuk; P S Lagali; P W Wong; I M MacDonald; P A Sieving; D J Figueroa; C P Austin; R J Gould; R Ayyagari; K Petrukhin Journal: Nat Genet Date: 2001-01 Impact factor: 38.330
Authors: A E Leonard; E G Bobik; J Dorado; P E Kroeger; L T Chuang; J M Thurmond; J M Parker-Barnes; T Das; Y S Huang; P Mukerji Journal: Biochem J Date: 2000-09-15 Impact factor: 3.857
Authors: P Thonneau; S Marchand; A Tallec; M L Ferial; B Ducot; J Lansac; P Lopes; J M Tabaste; A Spira Journal: Hum Reprod Date: 1991-07 Impact factor: 6.918
Authors: Emina Mocevic; Ina O Specht; Jacob L Marott; Aleksander Giwercman; Bo A G Jönsson; Gunnar Toft; Thomas Lundh; Jens Peter Bonde Journal: Asian J Androl Date: 2012-12-10 Impact factor: 3.285