Literature DB >> 22410789

Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies.

Esther Vázquez1, José L Corchero, Joan F Burgueño, Joaquin Seras-Franzoso, Ana Kosoy, Ramon Bosser, Rosa Mendoza, Joan Marc Martínez-Láinez, Ursula Rinas, Ester Fernández, Luis Ruiz-Avila, Elena García-Fruitós, Antonio Villaverde.   

Abstract

Inclusion bodies (50-500 nm in diameter) produced in recombinant bacteria can be engineered to contain functional proteins with therapeutic potential. Upon exposure, these protein particles are efficiently internalized by mammalian cells and promote recovery from diverse stresses. Being fully biocompatible, inclusion bodies are a novel platform, as tailored nanopills, for sustained drug release in advanced cell therapies.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22410789     DOI： 10.1002/adma.201104330

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  19 in total

Review 1.  Protein based therapeutic delivery agents: Contemporary developments and challenges.

Authors:  Liming Yin; Carlo Yuvienco; Jin Kim Montclare
Journal:  Biomaterials       Date:  2017-04-21       Impact factor: 12.479

2.  Purification of Inclusion Bodies Produced in Bacteria and Yeast.

Authors:  Joaquin Seras-Franzoso; Olivia Cano-Garrido; Spela Peternel; Anna Arís; Elena Garcia-Fruitós
Journal:  Methods Mol Biol       Date:  2022

3.  Inclusion bodies as potential vehicles for recombinant protein delivery into epithelial cells.

Authors:  Mirjana Liovic; Mateja Ozir; Apolonija Bedina Zavec; Spela Peternel; Radovan Komel; Tina Zupancic
Journal:  Microb Cell Fact       Date:  2012-05-24       Impact factor: 5.328

4.  Modeling amyloids in bacteria.

Authors:  Anna Villar-Piqué; Salvador Ventura
Journal:  Microb Cell Fact       Date:  2012-12-28       Impact factor: 5.328

5.  Packaging protein drugs as bacterial inclusion bodies for therapeutic applications.

Authors:  Antonio Villaverde; Elena García-Fruitós; Ursula Rinas; Joaquin Seras-Franzoso; Ana Kosoy; José Luis Corchero; Esther Vazquez
Journal:  Microb Cell Fact       Date:  2012-06-11       Impact factor: 5.328

6.  Functional inclusion bodies produced in the yeast Pichia pastoris.

Authors:  Fabián Rueda; Brigitte Gasser; Alejandro Sánchez-Chardi; Mònica Roldán; Sandra Villegas; Verena Puxbaum; Neus Ferrer-Miralles; Ugutz Unzueta; Esther Vázquez; Elena Garcia-Fruitós; Diethard Mattanovich; Antonio Villaverde
Journal:  Microb Cell Fact       Date:  2016-10-01       Impact factor: 5.328

7.  Bacterial inclusion bodies as potential synthetic devices for pathogen recognition and a therapeutic substance release.

Authors:  Klaudia Talafová; Eva Hrabárová; Dušan Chorvát; Jozef Nahálka
Journal:  Microb Cell Fact       Date:  2013-02-07       Impact factor: 5.328

Review 8.  Inclusion bodies: not that bad….

Authors:  Ana Ramón; Mario Señorale-Pose; Mónica Marín
Journal:  Front Microbiol       Date:  2014-02-14       Impact factor: 5.640

9.  A variant of green fluorescent protein exclusively deposited to active intracellular inclusion bodies.

Authors:  Govindan Raghunathan; Ganapathiraman Munussami; Hyojin Moon; Hyun-jong Paik; Seong Soo A An; Yong-Sung Kim; Sebyung Kang; Sun-Gu Lee
Journal:  Microb Cell Fact       Date:  2014-05-16       Impact factor: 5.328

10.  Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms.

Authors:  Débora Torrealba; Joaquin Seras-Franzoso; Uwe Mamat; Kathleen Wilke; Antonio Villaverde; Nerea Roher; Elena Garcia-Fruitós
Journal:  PLoS One       Date:  2016-10-07       Impact factor: 3.240
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