Literature DB >> 22396900

Down syndrome: is it really characterized by precocious immunosenescence?

Maaike Aa Kusters1, Ruud Hj Verstegen, Esther de Vries.   

Abstract

The immune system declines with aging, leading to an increased susceptibility to infections and higher incidence and progression of autoimmune phenomena and neoplasia. Down syndrome prematurely shows clinical manifestations that are normally seen with aging. This review provides a concise overview of abnormalities in the adaptive immune system of Down syndrome in comparison to normal and precocious (Progeria syndromes) aging. Clinical signs and immunological changes are reviewed. We challenge the hypothesis that the immunological abnormalities in Down syndrome should be interpreted as precocious immunosenescence.

Entities:  

Keywords:  Adaptive immune system; Down syndrome; Immunosenescence; Progeria syndromes

Year:  2011        PMID： 22396900      PMCID： PMC3295065     

Source DB:  PubMed          Journal:  Aging Dis        ISSN： 2152-5250            Impact factor:   6.745


  41 in total

Review 1.  Progeria syndromes and ageing: what is the connection?

Authors:  Christopher R Burtner; Brian K Kennedy
Journal:  Nat Rev Mol Cell Biol       Date:  2010-08       Impact factor: 94.444

2.  Intrinsic abnormalities of lymphocyte counts in children with down syndrome.

Authors:  Yvette C M de Hingh; Petrus W van der Vossen; Eugenie F A Gemen; André B Mulder; Wim C J Hop; Frank Brus; Esther de Vries
Journal:  J Pediatr       Date:  2005-12       Impact factor: 4.406

3.  Immune evaluation and vaccine responses in Down syndrome: evidence of immunodeficiency?

Authors:  Avni Y Joshi; Roshini S Abraham; Melissa R Snyder; Thomas G Boyce
Journal:  Vaccine       Date:  2011-05-17       Impact factor: 3.641

4.  Cancers and immune related diseases associated with Down's syndrome: a record linkage study.

Authors:  M J Goldacre; C J Wotton; V Seagroatt; D Yeates
Journal:  Arch Dis Child       Date:  2004-11       Impact factor: 3.791

5.  Antibody response to pneumococcal capsular polysaccharide vaccine in Down syndrome patients.

Authors:  B T Costa-Carvalho; R M A Martinez; A T N Dias; C A Kubo; P Barros-Nunes; L Leiva; D Solé; M M S Carneiro-Sampaio; C K Naspitz; R U Sorensen
Journal:  Braz J Med Biol Res       Date:  2006-12       Impact factor: 2.590

6.  Both normal memory counts and decreased naive cells favor intrinsic defect over early senescence of Down syndrome T lymphocytes.

Authors:  Maaike A A Kusters; Eugenie F A Gemen; Ruud H J Verstegen; Peter C Wever; Esther DE Vries
Journal:  Pediatr Res       Date:  2010-05       Impact factor: 3.756

7.  Abnormalities of the in vitro cellular and humoral responses to tetanus and influenza antigens with concomitant numerical alterations in lymphocyte subsets in Down syndrome (trisomy 21).

Authors:  R Philip; A C Berger; N H McManus; N H Warner; M A Peacock; L B Epstein
Journal:  J Immunol       Date:  1986-03-01       Impact factor: 5.422

Review 8.  Intrinsic defect of the immune system in children with Down syndrome: a review.

Authors:  M A A Kusters; R H J Verstegen; E F A Gemen; E de Vries
Journal:  Clin Exp Immunol       Date:  2009-01-22       Impact factor: 4.330

9.  Phenotype and course of Hutchinson-Gilford progeria syndrome.

Authors:  Melissa A Merideth; Leslie B Gordon; Sarah Clauss; Vandana Sachdev; Ann C M Smith; Monique B Perry; Carmen C Brewer; Christopher Zalewski; H Jeffrey Kim; Beth Solomon; Brian P Brooks; Lynn H Gerber; Maria L Turner; Demetrio L Domingo; Thomas C Hart; Jennifer Graf; James C Reynolds; Andrea Gropman; Jack A Yanovski; Marie Gerhard-Herman; Francis S Collins; Elizabeth G Nabel; Richard O Cannon; William A Gahl; Wendy J Introne
Journal:  N Engl J Med       Date:  2008-02-07       Impact factor: 91.245

Review 10.  Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation.

Authors:  Jörg J Goronzy; Cornelia M Weyand
Journal:  Arthritis Res Ther       Date:  2003-08-08       Impact factor: 5.156
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  16 in total

1.  Is Immune Aging a Cause of Disease among the Elderly, or is it a Passive Indicator of General Decline of Physiologic Function?

Authors:  Abbe N Vallejo
Journal:  Aging Dis       Date:  2011-12-02       Impact factor: 6.745

2.  A Prevalent CXCR3+ Phenotype of Circulating Follicular Helper T Cells Indicates Humoral Dysregulation in Children with Down Syndrome.

Authors:  Giorgio Ottaviano; Jolanda Gerosa; Micaela Santini; Pasqualina De Leo; Andrea Vecchione; Tatiana Jofra; Cristiana Trimarchi; Maurizio De Pellegrin; Massimo Agosti; Alessandro Aiuti; Maddalena Marinoni; Maria Pia Cicalese; Georgia Fousteri
Journal:  J Clin Immunol       Date:  2020-01-28       Impact factor: 8.317

3.  Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.

Authors:  Katharina Lambert; Keagan G Moo; Azlann Arnett; Gautam Goel; Alex Hu; Kaitlin J Flynn; Cate Speake; Alice E Wiedeman; Vivian H Gersuk; Peter S Linsley; Carla J Greenbaum; S Alice Long; Rebecca Partridge; Jane H Buckner; Bernard Khor
Journal:  Sci Transl Med       Date:  2022-01-12       Impact factor: 19.319

4.  A Difficult and Rare Diagnosis of Autoimmune Enteropathy in a Patient Affected by Down Syndrome.

Authors:  Anne Depince-Berger; Clara Cremilieux; Melanie Rinaudo-Gaujous; Christian Genin; Benedicte de Freminville; Claude Lambert; J Bruneau; Stephane Paul
Journal:  J Clin Immunol       Date:  2016-04-12       Impact factor: 8.317

5.  Identification of a DNA methylation signature in blood cells from persons with Down Syndrome.

Authors:  Maria Giulia Bacalini; Davide Gentilini; Alessio Boattini; Enrico Giampieri; Chiara Pirazzini; Cristina Giuliani; Elisa Fontanesi; Maria Scurti; Daniel Remondini; Miriam Capri; Guido Cocchi; Alessandro Ghezzo; Alberto Del Rio; Donata Luiselli; Giovanni Vitale; Daniela Mari; Gastone Castellani; Mario Fraga; Anna Maria Di Blasio; Stefano Salvioli; Claudio Franceschi; Paolo Garagnani
Journal:  Aging (Albany NY)       Date:  2015-02       Impact factor: 5.682

6.  Accelerated epigenetic aging in Down syndrome.

Authors:  Steve Horvath; Paolo Garagnani; Maria Giulia Bacalini; Chiara Pirazzini; Stefano Salvioli; Davide Gentilini; Anna Maria Di Blasio; Cristina Giuliani; Spencer Tung; Harry V Vinters; Claudio Franceschi
Journal:  Aging Cell       Date:  2015-02-09       Impact factor: 9.304

7.  The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain.

Authors:  Jianhui Wang; Xiaorui Cheng; Xiaorui Zhang; Junping Cheng; Yiran Xu; Ju Zeng; Wenxia Zhou; Yongxiang Zhang
Journal:  Oncotarget       Date:  2016-05-10

Review 8.  Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome.

Authors:  Tomer Illouz; Arya Biragyn; Maria Florencia Iulita; Lisi Flores-Aguilar; Mara Dierssen; Ilario De Toma; Stylianos E Antonarakis; Eugene Yu; Yann Herault; Marie-Claude Potier; Alexandra Botté; Randall Roper; Benjamin Sredni; Jacqueline London; William Mobley; Andre Strydom; Eitan Okun
Journal:  Front Immunol       Date:  2021-06-25       Impact factor: 7.561

9.  Alterations and chromosomal variants in the Ecuadorian population.

Authors:  César Paz-y-Miño; Nadia Cumbal; Santiago Araujo; Ma Eugenia Sánchez
Journal:  J Biomed Biotechnol       Date:  2012-10-02

10.  LW-AFC, a new formula derived from Liuwei Dihuang decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1ΔE9 transgenic mice.

Authors:  Jian-Hui Wang; Xi Lei; Xiao-Rui Cheng; Xiao-Rui Zhang; Gang Liu; Jun-Ping Cheng; Yi-Ran Xu; Ju Zeng; Wen-Xia Zhou; Yong-Xiang Zhang
Journal:  Alzheimers Res Ther       Date:  2016-12-13       Impact factor: 6.982
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