Literature DB >> 22396158

Intracellular conformations of human telomeric quadruplexes studied by electron paramagnetic resonance spectroscopy.

Mykhailo Azarkh1, Vijay Singh, Oliver Okle, Daniel R Dietrich, Jörg S Hartig, Malte Drescher.   

Abstract

In-cell DEER (in-cell double electron electron resonance) is applied to investigate quadruplex formation of the human telomeric repeat d[AGGG(TTAGGG)(3)]. The initially unfolded DNA sequence forms a mixture of different quadruplex topologies upon injection into living cells. In addition, time-dependent distance measurements are carried out to monitor quadruplex folding.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22396158     DOI： 10.1002/cphc.201100980

Source DB:  PubMed          Journal:  Chemphyschem        ISSN： 1439-4235            Impact factor:   3.102


  8 in total

1.  Site-directed spin-labeling of nucleotides and the use of in-cell EPR to determine long-range distances in a biologically relevant environment.

Authors:  Mykhailo Azarkh; Vijay Singh; Oliver Okle; Isabelle T Seemann; Daniel R Dietrich; Jörg S Hartig; Malte Drescher
Journal:  Nat Protoc       Date:  2012-12-20       Impact factor: 13.491

Review 2.  New NMR tools for protein structure and function: Spin tags for dynamic nuclear polarization solid state NMR.

Authors:  Rivkah Rogawski; Ann E McDermott
Journal:  Arch Biochem Biophys       Date:  2017-06-13       Impact factor: 4.013

3.  Conformations of Human Telomeric G-Quadruplex Studied Using a Nucleotide-Independent Nitroxide Label.

Authors:  Xiaojun Zhang; Cui-Xia Xu; Rosa Di Felice; Jiri Sponer; Barira Islam; Petr Stadlbauer; Yuan Ding; Lingling Mao; Zong-Wan Mao; Peter Z Qin
Journal:  Biochemistry       Date:  2015-12-31       Impact factor: 3.162

4.  Distance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexes.

Authors:  M P Donohue; V A Szalai
Journal:  Phys Chem Chem Phys       Date:  2016-06-01       Impact factor: 3.676

5.  A Dual-App Nucleoside Probe Provides Structural Insights into the Human Telomeric Overhang in Live Cells.

Authors:  Sudeshna Manna; Debayan Sarkar; Seergazhi G Srivatsan
Journal:  J Am Chem Soc       Date:  2018-09-21       Impact factor: 15.419

6.  Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA.

Authors:  Petra Školáková; Silvie Foldynová-Trantírková; Klára Bednářová; Radovan Fiala; Michaela Vorlíčková; Lukáš Trantírek
Journal:  Nucleic Acids Res       Date:  2015-04-08       Impact factor: 16.971

7.  Gd(III)-Gd(III) Relaxation-Induced Dipolar Modulation Enhancement for In-Cell Electron Paramagnetic Resonance Distance Determination.

Authors:  Mykhailo Azarkh; Anna Bieber; Mian Qi; Jörg W A Fischer; Maxim Yulikov; Adelheid Godt; Malte Drescher
Journal:  J Phys Chem Lett       Date:  2019-03-18       Impact factor: 6.475

8.  In-Cell Trityl-Trityl Distance Measurements on Proteins.

Authors:  Yin Yang; Bin-Bin Pan; Xiaoli Tan; Feng Yang; Yangping Liu; Xun-Cheng Su; Daniella Goldfarb
Journal:  J Phys Chem Lett       Date:  2020-01-28       Impact factor: 6.475
  8 in total

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