Yong Jin1, Bo-You Li, Ling-Li Qiu, Yuan-Ren Ling, Zhi-Qiang Bai. 1. Department of Neurosurgery, Affiliated Taizhou Municipal Hospital, Taizhou University, Jiaojiang District, Taizhou 318000, China. taizhoujinyong@163.com
Abstract
PURPOSE: Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients. METHODS: One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA. RESULTS: Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score. CONCLUSIONS: Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.
PURPOSE: Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients. METHODS: One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA. RESULTS: Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score. CONCLUSIONS: Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.
Authors: Zoltán Horváth-Szalai; Péter Kustán; Balázs Szirmay; Ágnes Lakatos; Per H Christensen; Tamás Huber; Beáta Bugyi; Diána Mühl; Andrea Ludány; Attila Miseta; Gábor L Kovács; Tamás Kőszegi Journal: J Clin Lab Anal Date: 2017-09-05 Impact factor: 2.352
Authors: Jon Hazeldine; Robert J Dinsdale; David N Naumann; Animesh Acharjee; Jonathan R B Bishop; Janet M Lord; Paul Harrison Journal: Burns Trauma Date: 2021-04-01