Literature DB >> 22385648

Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate.

Ye-Guang Chen1, Zhongwei Li, Xiao-Fan Wang.   

Abstract

Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3β/β-catenin signaling. Copyright Â
© 2012 Elsevier Inc. All rights reserved.

Entities:  

Year:  2012        PMID： 22385648      PMCID： PMC3586792          DOI： 10.1016/j.stem.2012.02.008

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.

Authors:  C Rommel; B A Clarke; S Zimmermann; L Nuñez; R Rossman; K Reid; K Moelling; G D Yancopoulos; D J Glass
Journal:  Science       Date:  1999-11-26       Impact factor: 47.728

Review 2.  Extrinsic regulation of pluripotent stem cells.

Authors:  Martin F Pera; Patrick P L Tam
Journal:  Nature       Date:  2010-06-10       Impact factor: 49.962

3.  Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal.

Authors:  Jie Na; Miho K Furue; Peter W Andrews
Journal:  Stem Cell Res       Date:  2010-08-03       Impact factor: 2.020

4.  BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.

Authors:  Zhongwei Li; Teng Fei; Jianping Zhang; Gaoyang Zhu; Lu Wang; Danyu Lu; Xiaochun Chi; Yan Teng; Ning Hou; Xiao Yang; Hongquan Zhang; Jing-Dong J Han; Ye-Guang Chen
Journal:  Cell Stem Cell       Date:  2012-02-03       Impact factor: 24.633

5.  The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

Authors:  Lyle Armstrong; Owen Hughes; Sun Yung; Louise Hyslop; Rebecca Stewart; Ilka Wappler; Heiko Peters; Theresia Walter; Petra Stojkovic; Jerome Evans; Miodrag Stojkovic; Majlinda Lako
Journal:  Hum Mol Genet       Date:  2006-04-27       Impact factor: 6.150

6.  MEK/ERK signaling contributes to the maintenance of human embryonic stem cell self-renewal.

Authors:  Jian Li; Guangwen Wang; Chengyan Wang; Yang Zhao; Hong Zhang; Zhijia Tan; Zhihua Song; Mingxiao Ding; Hongkui Deng
Journal:  Differentiation       Date:  2007-02-05       Impact factor: 3.880

7.  Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation.

Authors:  Amar M Singh; David Reynolds; Timothy Cliff; Satoshi Ohtsuka; Alexa L Mattheyses; Yuhua Sun; Laura Menendez; Michael Kulik; Stephen Dalton
Journal:  Cell Stem Cell       Date:  2012-03-02       Impact factor: 24.633

8.  Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.

Authors:  Qingqing Ding; Weiya Xia; Jaw-Ching Liu; Jer-Yen Yang; Dung-Fang Lee; Jiahong Xia; Geoffrey Bartholomeusz; Yan Li; Yong Pan; Zheng Li; Ralf C Bargou; Jun Qin; Chien-Chen Lai; Fuu-Jen Tsai; Chang-Hai Tsai; Mien-Chie Hung
Journal:  Mol Cell       Date:  2005-07-22       Impact factor: 17.970

9.  Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor.

Authors:  Noboru Sato; Laurent Meijer; Leandros Skaltsounis; Paul Greengard; Ali H Brivanlou
Journal:  Nat Med       Date:  2003-12-21       Impact factor: 53.440

10.  The ground state of embryonic stem cell self-renewal.

Authors:  Qi-Long Ying; Jason Wray; Jennifer Nichols; Laura Batlle-Morera; Bradley Doble; James Woodgett; Philip Cohen; Austin Smith
Journal:  Nature       Date:  2008-05-22       Impact factor: 49.962
  10 in total
  14 in total

1.  Transforming growth factor-β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response.

Authors:  Dana Duan; Rik Derynck
Journal:  J Biol Chem       Date:  2019-04-04       Impact factor: 5.157

2.  SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.

Authors:  Xiaoya Ma; Nupur K Das; Cristina Castillo; Ayla Gourani; Ansu O Perekatt; Michael P Verzi; Yatrik M Shah
Journal:  J Biol Chem       Date:  2019-01-18       Impact factor: 5.157

3.  PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.

Authors:  Jason S L Yu; Thamil Selvee Ramasamy; Nick Murphy; Marie K Holt; Rafal Czapiewski; Shi-Khai Wei; Wei Cui
Journal:  Nat Commun       Date:  2015-05-22       Impact factor: 14.919

4.  MiR-223 regulates human embryonic stem cell differentiation by targeting the IGF-1R/Akt signaling pathway.

Authors:  Yan-Hui Yu; Li Zhang; Deng-Shu Wu; Zheng Zhang; Fang-Fang Huang; Jian Zhang; Xiao-Ping Chen; De-Sheng Liang; Hui Zeng; Fang-Ping Chen
Journal:  PLoS One       Date:  2013-11-08       Impact factor: 3.240

5.  CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency.

Authors:  Xiao Qi Wang; Chung Mau Lo; Lin Chen; Elly S-W Ngan; Aimin Xu; Randy Yc Poon
Journal:  Cell Death Differ       Date:  2016-09-16       Impact factor: 15.828

6.  Transcriptome variations among human embryonic stem cell lines are associated with their differentiation propensity.

Authors:  Changbin Sun; Jiawen Zhang; Dongmin Zheng; Jian Wang; Huanming Yang; Xi Zhang
Journal:  PLoS One       Date:  2018-02-14       Impact factor: 3.240

7.  Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/β-catenin pathway.

Authors:  Xinye Han; Peipei Wu; Linli Li; Hassan Mohamud Sahal; Cheng Ji; Jiahui Zhang; Yi Wang; Qichen Wang; Hui Qian; Hui Shi; Wenrong Xu
Journal:  Cell Cycle       Date:  2021-03-08       Impact factor: 4.534

8.  Continuous hypoxic culturing of human embryonic stem cells enhances SSEA-3 and MYC levels.

Authors:  Elisa Närvä; Juha-Pekka Pursiheimo; Asta Laiho; Nelly Rahkonen; Maheswara Reddy Emani; Miro Viitala; Kirsti Laurila; Roosa Sahla; Riikka Lund; Harri Lähdesmäki; Panu Jaakkola; Riitta Lahesmaa
Journal:  PLoS One       Date:  2013-11-13       Impact factor: 3.240

9.  Non-tumor tissue derived interleukin-17B activates IL-17RB/AKT/β-catenin pathway to enhance the stemness of gastric cancer.

Authors:  Qingli Bie; Caixia Sun; Aihua Gong; Chunye Li; Zhaoliang Su; Dong Zheng; Xiaoyun Ji; Yumin Wu; Qi Guo; Shengjun Wang; Huaxi Xu
Journal:  Sci Rep       Date:  2016-05-05       Impact factor: 4.379

10.  Correlation of GOLPH3 Gene with Wnt Signaling Pathway in Human Colon Cancer Cells.

Authors:  Cheng-Zhi Qiu; Ming-Zhen Wang; Wai-Shi Yu; Yan-Ta Guo; Chun-Xiao Wang; Xiao-Feng Yang
Journal:  J Cancer       Date:  2016-05-07       Impact factor: 4.207
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