| Literature DB >> 22383037 |
Astrid Junker1, Hendrik Rohn, Tobias Czauderna, Christian Klukas, Anja Hartmann, Falk Schreiber.
Abstract
The Systems Biology Graphical Notation (SBGN) is an emerging standard for the uniform representation of biological processes and networks. By using examples from gene regulation and metabolism, this protocol shows the construction of SBGN maps by either manual drawing or automatic translation using the tool SBGN-ED. In addition, it discusses the enrichment of SBGN maps with different kinds of -omics data to bring numerical data into the context of these networks in order to facilitate the interpretation of experimental data. Finally, the export of such maps to public websites, including clickable images, supports the communication of results within the scientific community. With regard to the described functionalities, other tools partially overlap with SBGN-ED. However, currently, SBGN-ED is the only tool that combines all of these functions, including the representation in SBGN, data mapping and website export. This protocol aims to assist scientists with the step-by-step procedure, which altogether takes ∼90 min.Mesh：
Year: 2012 PMID： 22383037 DOI： 10.1038/nprot.2012.002
Source DB: PubMed Journal: Nat Protoc ISSN： 1750-2799 Impact factor: 13.491