Literature DB >> 22382814

Myricetin facilitates potassium currents and inhibits neuronal activity of PVN neurons.

ZeGang Ma1, TianWei Liu.   

Abstract

The effects of myricetin on hypothalamic paraventricular nucleus (PVN) neurons in rats were investigated. By whole-cell patch clamp detection in hypothalamic brain slices, we showed that the action potential frequency in type-I PVN neurons dose-dependently decreased after myricetin treatment. Further studies demonstrated that myricetin may enhance potassium currents and shifts the voltage-dependence of activation of potassium currents to more negative potentials by 6.07 mV. Using calcium free/cadmium perfusion solution could reverse myricetin-induced enhancement of potassium currents in PVN neurons. These results suggested that inhibition of hypothalamic PVN neurons by myricetin might be attributed to the enhancement of potassium currents.

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Year:  2012        PMID： 22382814     DOI： 10.1007/s11064-012-0732-2

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  27 in total

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6.  Effects of chemical stimulation of paraventricular nucleus on adrenal and renal nerve activity in rats.

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9.  Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.

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Authors:  T Kawabe; V C Chitravanshi; K Kawabe; H N Sapru
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  9 in total

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Review 8.  Natural Polyphenols as SERCA Activators: Role in the Endoplasmic Reticulum Stress-Related Diseases.

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9.  Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress.

Authors:  Zegang Ma; Guilin Wang; Lin Cui; Qimin Wang
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  9 in total

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