Literature DB >> 22374802

Discovery of macrocyclic peptides armed with a mechanism-based warhead: isoform-selective inhibition of human deacetylase SIRT2.

Jumpei Morimoto1, Yuuki Hayashi, Hiroaki Suga.   

Abstract

Designed to inhibit: by using the random nonstandard peptide integrated discovery (RaPID) system, highly potent isoform-selective inhibitors can be identified from a library of nonstandard macrocyclic peptides. These inhibitors, which contain a mechanism-based warhead residue, are active against the human deacetylase SIRT2, with IC(50) values in the low nanomolar region.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 22374802     DOI： 10.1002/anie.201108118

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  27 in total

1.  A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM.

Authors:  Kazuhiro Iwasaki; Yuki Goto; Takayuki Katoh; Taro Yamashita; Shuichi Kaneko; Hiroaki Suga
Journal:  J Mol Evol       Date:  2015-11-09       Impact factor: 2.395

2.  Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids.

Authors:  John R Frost; Nicholas T Jacob; Louis J Papa; Andrew E Owens; Rudi Fasan
Journal:  ACS Chem Biol       Date:  2015-05-15       Impact factor: 5.100

3.  Structural basis for the drug extrusion mechanism by a MATE multidrug transporter.

Authors:  Yoshiki Tanaka; Christopher J Hipolito; Andrés D Maturana; Koichi Ito; Teruo Kuroda; Takashi Higuchi; Takayuki Katoh; Hideaki E Kato; Motoyuki Hattori; Kaoru Kumazaki; Tomoya Tsukazaki; Ryuichiro Ishitani; Hiroaki Suga; Osamu Nureki
Journal:  Nature       Date:  2013-03-27       Impact factor: 49.962

4.  Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes.

Authors:  Yoshihiko Iwane; Azusa Hitomi; Hiroshi Murakami; Takayuki Katoh; Yuki Goto; Hiroaki Suga
Journal:  Nat Chem       Date:  2016-02-01       Impact factor: 24.427

Review 5.  tRNA engineering for manipulating genetic code.

Authors:  Takayuki Katoh; Yoshihiko Iwane; Hiroaki Suga
Journal:  RNA Biol       Date:  2017-09-06       Impact factor: 4.652

Review 6.  A Genetically Encoded, Phage-Displayed Cyclic-Peptide Library.

Authors:  Xiaoshan Shayna Wang; Peng-Hsun Chase Chen; J Trae Hampton; Jeffery M Tharp; Catrina A Reed; Sukant K Das; Duen-Shian Wang; Hamed S Hayatshahi; Yang Shen; Jin Liu; Wenshe Ray Liu
Journal:  Angew Chem Int Ed Engl       Date:  2019-09-09       Impact factor: 15.336

7.  Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.

Authors:  Joshua Schwochert; Yongtong Lao; Cameron R Pye; Matthew R Naylor; Prashant V Desai; Isabel C Gonzalez Valcarcel; Jaclyn A Barrett; Geri Sawada; Maria-Jesus Blanco; R Scott Lokey
Journal:  ACS Med Chem Lett       Date:  2016-06-06       Impact factor: 4.345

Review 8.  Sirtuin inhibitors as anticancer agents.

Authors:  Jing Hu; Hui Jing; Hening Lin
Journal:  Future Med Chem       Date:  2014-05       Impact factor: 3.808

9.  Side-chain-to-tail cyclization of ribosomally derived peptides promoted by aryl and alkyl amino-functionalized unnatural amino acids.

Authors:  John R Frost; Zhijie Wu; Yick Chong Lam; Andrew E Owens; Rudi Fasan
Journal:  Org Biomol Chem       Date:  2016-04-11       Impact factor: 3.876

10.  An efficient strategy to enhance binding affinity and specificity of a known isozyme inhibitor.

Authors:  Joo-Eun Jee; Jaehong Lim; Yong Siang Ong; Jessica Oon; Liqian Gao; Hak Soo Choi; Su Seong Lee
Journal:  Org Biomol Chem       Date:  2016-07-12       Impact factor: 3.876
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