Shinya Wada1, Seiji Hobo, Hirotaka Ode, Hidekazu Niwa, Hidekazu Moriyama. 1. Clinical Science and Pathobiology Division, Equine Research Institute ERI, The Japan Racing Association JRA, 321-4, Tokami-cho, Utsunomiya, Tochigi 320-0856, Japan. shinya_wada@jra.go.jp
Abstract
OBJECTIVE: To describe the incidence, clinical progress, visual outcome, and laboratory findings of equine keratomycosis in Japan. PROCEDURE: Retrospective study of the medical records of horses clinically and mycologically diagnosed with keratomycosis at the Equine Hospitals of the Japan Racing Association from 2005 to 2011. RESULTS: The diagnosis of keratomycosis was confirmed in eight horses (40.0% of the 20 horses with infectious keratitis from which fungi and/or bacteria were isolated). Fungi recovered from corneal swabs were identified as Aspergillus flavus (4), Aspergillus niger (1), Fusarium solani (1), and Mortierella wolfii (2). All horses were treated medically with topical antifungals, and one horse was also treated surgically. The median of treatment period was 40 days. Two horses were rendered blind in the affected eye and the others retained vision. CONCLUSIONS: Equine keratomycosis comprises a considerable portion of infectious keratitis in Japan, and the causative fungi that we isolated had been isolated previously from horses with keratomycosis in other regions with the exception of M. wolfii. Culture and cytological examination of corneal lesions should be immediately performed on eyes with signs of keratitis, particularly on those not improving with antibacterial medication, as early initiation of aggressive antifungal treatment tended to result in better outcome and shorter treatment period.
OBJECTIVE: To describe the incidence, clinical progress, visual outcome, and laboratory findings of equine keratomycosis in Japan. PROCEDURE: Retrospective study of the medical records of horses clinically and mycologically diagnosed with keratomycosis at the Equine Hospitals of the Japan Racing Association from 2005 to 2011. RESULTS: The diagnosis of keratomycosis was confirmed in eight horses (40.0% of the 20 horses with infectious keratitis from which fungi and/or bacteria were isolated). Fungi recovered from corneal swabs were identified as Aspergillus flavus (4), Aspergillus niger (1), Fusarium solani (1), and Mortierella wolfii (2). All horses were treated medically with topical antifungals, and one horse was also treated surgically. The median of treatment period was 40 days. Two horses were rendered blind in the affected eye and the others retained vision. CONCLUSIONS:Equine keratomycosis comprises a considerable portion of infectious keratitis in Japan, and the causative fungi that we isolated had been isolated previously from horses with keratomycosis in other regions with the exception of M. wolfii. Culture and cytological examination of corneal lesions should be immediately performed on eyes with signs of keratitis, particularly on those not improving with antibacterial medication, as early initiation of aggressive antifungal treatment tended to result in better outcome and shorter treatment period.
Authors: Selwyn Arlington Headley; Pedro Henrique de Carvalho; Luiz Fernando C Cunha Filho; Aline Artioli Machado Yamamura; Werner Okano Journal: Mycopathologia Date: 2014-01-24 Impact factor: 2.574
Authors: Seyedmojtaba Seyedmousavi; Sandra de M G Bosco; Sybren de Hoog; Frank Ebel; Daniel Elad; Renata R Gomes; Ilse D Jacobsen; Henrik Elvang Jensen; An Martel; Bernard Mignon; Frank Pasmans; Elena Piecková; Anderson Messias Rodrigues; Karuna Singh; Vania A Vicente; Gudrun Wibbelt; Nathan P Wiederhold; Jacques Guillot Journal: Med Mycol Date: 2018-04-01 Impact factor: 4.076
Authors: Megan Cullen; Megan E Jacob; Vicki Cornish; Ian Q VanderSchel; Henry Van T Cotter; Marc A Cubeta; Ignazio Carbone; Brian C Gilger Journal: PLoS One Date: 2019-03-28 Impact factor: 3.240