| Literature DB >> 22366088 |
Arvind M Korwar1, Hemangi S Bhonsle, Ashok D Chougale, Sachin S Kote, Kachru R Gawai, Vikram S Ghole, Chaitanyananda B Koppikar, Mahesh J Kulkarni.
Abstract
Cancer is associated with increased glycolysis and carbonyl stress. In view of this, AGE modified proteins were identified from clinical breast cancer tissue using 2DE-immunoblot and mass-spectrometry. These proteins were identified to be serotransferrin, fibrinogen gamma chain, glycerol-3-phosphate dehydrogenase, lactate dehydrogenase, annexin II, prohibitin and peroxiredoxin 6, which have established role in cancer. Further, RAGE expression and its downstream signaling proteins NADPH oxidase and NF-kB were studied. Role of these AGE modified proteins and RAGE signaling in breast cancer is discussed. Copyright ÂEntities:
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Year: 2012 PMID： 22366088 DOI： 10.1016/j.bbrc.2012.02.039
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575