Literature DB >> 22365614

The symphony of the ninth: the development and function of Th9 cells.

Rukhsana Jabeen1, Mark H Kaplan.   

Abstract

CD4+ T helper cells are obligate regulators of inflammatory disease. An expanding cadre of T helper (Th) subsets, specialized for promoting particular types of inflammation, function through the secretion of a restricted set of cytokines. The latest addition to the list of subsets is the Th9 cell that secretes IL-9 as a signature cytokine and contributes to several classes of inflammatory disease. In this review we focus on recent advances in understanding the development of Th9 cells, and how Th9 cells contribute to the orchestration of disease.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22365614      PMCID： PMC3368035          DOI： 10.1016/j.coi.2012.02.001

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  46 in total

1.  The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.

Authors:  Anne Brüstle; Sylvia Heink; Magdalena Huber; Christine Rosenplänter; Christine Stadelmann; Philipp Yu; Enrico Arpaia; Tak W Mak; Thomas Kamradt; Michael Lohoff
Journal:  Nat Immunol       Date:  2007-08-05       Impact factor: 25.606

2.  PU.1 expression delineates heterogeneity in primary Th2 cells.

Authors:  Hua-Chen Chang; Shangming Zhang; Vivian T Thieu; Roger B Slee; Heather A Bruns; R Nicholas Laribee; Michael J Klemsz; Mark H Kaplan
Journal:  Immunity       Date:  2005-06       Impact factor: 31.745

3.  IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.

Authors:  Michelle M Fung; Yen-Lin Chu; J Lynn Fink; Anne Wallace; Kathleen L McGuire
Journal:  Oncogene       Date:  2005-07-07       Impact factor: 9.867

4.  IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines.

Authors:  Ayele-Nati N Ahyi; Hua-Chen Chang; Alexander L Dent; Stephen L Nutt; Mark H Kaplan
Journal:  J Immunol       Date:  2009-07-10       Impact factor: 5.422

5.  Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells.

Authors:  John T O'Malley; Sarita Sehra; Vivian T Thieu; Qing Yu; Hua-Chen Chang; Gretta L Stritesky; Evelyn T Nguyen; Anubhav N Mathur; David E Levy; Mark H Kaplan
Journal:  Immunology       Date:  2009-08       Impact factor: 7.397

6.  Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

Authors:  Marc Veldhoen; Catherine Uyttenhove; Jacques van Snick; Helena Helmby; Astrid Westendorf; Jan Buer; Bruno Martin; Christoph Wilhelm; Brigitta Stockinger
Journal:  Nat Immunol       Date:  2008-10-19       Impact factor: 25.606

7.  Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells.

Authors:  Jun Wei; Omar Duramad; Olivia A Perng; Steven L Reiner; Yong-Jun Liu; F Xiao-Feng Qin
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-31       Impact factor: 11.205

Review 8.  GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation.

Authors:  I-Cheng Ho; Tzong-Shyuan Tai; Sung-Yun Pai
Journal:  Nat Rev Immunol       Date:  2009-02       Impact factor: 53.106

9.  IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells.

Authors:  Valérie Dardalhon; Amit Awasthi; Hyoung Kwon; George Galileos; Wenda Gao; Raymond A Sobel; Meike Mitsdoerffer; Terry B Strom; Wassim Elyaman; I-Cheng Ho; Samia Khoury; Mohamed Oukka; Vijay K Kuchroo
Journal:  Nat Immunol       Date:  2008-11-09       Impact factor: 25.606

10.  GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.

Authors:  Pierre-Yves Mantel; Harmjan Kuipers; Onur Boyman; Claudio Rhyner; Nadia Ouaked; Beate Rückert; Christian Karagiannidis; Bart N Lambrecht; Rudolf W Hendriks; Reto Crameri; Cezmi A Akdis; Kurt Blaser; Carsten B Schmidt-Weber
Journal:  PLoS Biol       Date:  2007-12       Impact factor: 8.029
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  36 in total

Review 1.  Resolution of allergic asthma.

Authors:  Susetta Finotto
Journal:  Semin Immunopathol       Date:  2019-11-08       Impact factor: 9.623

Review 2.  Immunomodulatory effects of transforming growth factor-β in the liver.

Authors:  Hans-Theo Schon; Ralf Weiskirchen
Journal:  Hepatobiliary Surg Nutr       Date:  2014-12       Impact factor: 7.293

Review 3.  The good, the bad and the ugly - TFH cells in human health and disease.

Authors:  Stuart G Tangye; Cindy S Ma; Robert Brink; Elissa K Deenick
Journal:  Nat Rev Immunol       Date:  2013-05-17       Impact factor: 53.106

Review 4.  Transcriptional regulatory networks for CD4 T cell differentiation.

Authors:  Darah Christie; Jinfang Zhu
Journal:  Curr Top Microbiol Immunol       Date:  2014       Impact factor: 4.291

5.  Th2 cells as an intermediate for the differentiation of naïve T cells into Th9 cells, associated with the Smad3/Smad4 and IRF4 pathway.

Authors:  Mohamed Hamed Abdelaziz; Huixuan Wang; Jianjun Cheng; Huaxi Xu
Journal:  Exp Ther Med       Date:  2020-01-03       Impact factor: 2.447

6.  Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.

Authors:  Christoph Schlapbach; Ahmed Gehad; Chao Yang; Rei Watanabe; Emmanuella Guenova; Jessica E Teague; Laura Campbell; Nikhil Yawalkar; Thomas S Kupper; Rachael A Clark
Journal:  Sci Transl Med       Date:  2014-01-15       Impact factor: 17.956

7.  Th9 cell development requires a BATF-regulated transcriptional network.

Authors:  Rukhsana Jabeen; Ritobrata Goswami; Olufolakemi Awe; Aishwarya Kulkarni; Evelyn T Nguyen; Andrea Attenasio; Daniel Walsh; Matthew R Olson; Myung H Kim; Robert S Tepper; Jie Sun; Chang H Kim; Elizabeth J Taparowsky; Baohua Zhou; Mark H Kaplan
Journal:  J Clin Invest       Date:  2013-11       Impact factor: 14.808

8.  Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression.

Authors:  Wei Liao; Rosanne Spolski; Peng Li; Ning Du; Erin E West; Min Ren; Suman Mitra; Warren J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

9.  Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells.

Authors:  Ritobrata Goswami; Mark H Kaplan
Journal:  J Immunol       Date:  2012-08-17       Impact factor: 5.422

Review 10.  Characterization of CD4+ T cell subsets in allergy.

Authors:  Erik Wambre; Eddie A James; William W Kwok
Journal:  Curr Opin Immunol       Date:  2012-08-10       Impact factor: 7.486
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