Literature DB >> 22360674

Developing and delivering clinical pharmacology in pharmaceutical companies.

Duncan Richards1.   

Abstract

The challenges of developing new medicines are well known. Effective application of clinical pharmacology expertise is vital to the successful evaluation of potential new medicines. In drug development, this depends on effective integration of diverse skills. Many of these are currently in short supply, but through innovative partnerships between industry and academia there is an opportunity to reinvigorate the discipline by nurturing these key skills to the benefit of both partners. Specific areas of focus should be experimental medicine, modelling and simulation, and translational skills.
© 2012 The Author. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.

Mesh:

Year:  2012        PMID: 22360674      PMCID: PMC3391510          DOI: 10.1111/j.1365-2125.2012.04227.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN: 0306-5251            Impact factor:   4.335


  4 in total

1.  Rational prescribing, appropriate prescribing.

Authors:  J K Aronson
Journal:  Br J Clin Pharmacol       Date:  2004-03       Impact factor: 4.335

Review 2.  Pharmacokinetics/Pharmacodynamics and the stages of drug development: role of modeling and simulation.

Authors:  Jenny Y Chien; Stuart Friedrich; Michael A Heathman; Dinesh P de Alwis; Vikram Sinha
Journal:  AAPS J       Date:  2005-10-07       Impact factor: 4.009

3.  Trial watch: Phase II failures: 2008-2010.

Authors:  John Arrowsmith
Journal:  Nat Rev Drug Discov       Date:  2011-05       Impact factor: 84.694

4.  The role of predictive biopharmaceutical modeling and simulation in drug development and regulatory evaluation.

Authors:  Wenlei Jiang; Stephanie Kim; Xinyuan Zhang; Robert A Lionberger; Barbara M Davit; Dale P Conner; Lawrence X Yu
Journal:  Int J Pharm       Date:  2011-07-23       Impact factor: 5.875

  4 in total

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