Literature DB >> 22358962

Induction of DNA double strand breaks in cultured mammalian cells exposed to hydrogen peroxide and histidine.

O Cantoni1, P Sestili, F Cattabeni.   

Abstract

The amino acid histidine was found to increase the toxicity of H(2)O(2) in cultured mammalian cells. Histidine also augmented the level of DNA single strand breaks (SSB) detectable in cells exposed to the oxidant and, in addition, resulted in the appearance of DNA double strand breaks (DSB), a lesion which is not produced by H(2)O(2) alone.

Entities:  

Year:  1991        PMID： 22358962     DOI： 10.1007/BF00736816

Source DB:  PubMed          Journal:  Cytotechnology        ISSN： 0920-9069            Impact factor:   2.058


  6 in total

1.  Hydrogen peroxide insult in cultured mammalian cells: relationships between DNA single-strand breakage, poly(ADP-ribose) metabolism and cell killing.

Authors:  O Cantoni; F Cattabeni; V Stocchi; R E Meyn; P Cerutti; D Murray
Journal:  Biochim Biophys Acta       Date:  1989-10-30

2.  Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity.

Authors:  O Cantoni; P Sestili; F Cattabeni; G Bellomo; S Pou; M Cohen; P Cerutti
Journal:  Eur J Biochem       Date:  1989-06-15

3.  In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction.

Authors:  A C Mello Filho; R Meneghini
Journal:  Biochim Biophys Acta       Date:  1984-02-24

4.  Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron.

Authors:  A C Mello Filho; M E Hoffmann; R Meneghini
Journal:  Biochem J       Date:  1984-02-15       Impact factor: 3.857

5.  Histidine modulates the clastogenic effect of oxidative stress.

Authors:  P Tachon; P U Giacomoni
Journal:  Mutat Res       Date:  1989-03       Impact factor: 2.433

6.  The mechanism of pH-dependent hydrogen peroxide cytotoxicity in vitro.

Authors:  E M Link
Journal:  Arch Biochem Biophys       Date:  1988-09       Impact factor: 4.013
  6 in total
  1 in total

Review 1.  Endogenous Generation of Singlet Oxygen and Ozone in Human and Animal Tissues: Mechanisms, Biological Significance, and Influence of Dietary Components.

Authors:  Arnold N Onyango
Journal:  Oxid Med Cell Longev       Date:  2016-03-06       Impact factor: 6.543
  1 in total

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