OBJECTIVE: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. METHODS: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n=9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. RESULTS: The AUC of the ACRS, ACRS+9p21, ACRS+CIMT-P and ACRS+CIMT-P+9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). CONCLUSION: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.
OBJECTIVE: We evaluated whether the addition of carotid intima media thickness and plaque (CIMT-P), and a single nucleotide polymorphism on chromosome 9p21 (9p21) together improve coronary heart disease (CHD) risk prediction in the ARIC study. METHODS: Ten year CHD risk was estimated using the ARIC coronary risk score (ACRS) alone and in combination with CIMT-P and 9p21 individually and together in White participants (n=9338). Area under the receiver operating characteristic curve (AUC), model calibration, net reclassification index (NRI), integrated discrimination index (IDI) and number of individuals reclassified were estimated. RESULTS: The AUC of the ACRS, ACRS+9p21, ACRS+CIMT-P and ACRS+CIMT-P+9p21 models were 0.748, 0.751, 0.763 and 0.766 respectively. The percentage of individuals reclassified, model calibration, NRI and IDI improved when CIMT-P and 9p21 were added to the ACRS only model (see manuscript). CONCLUSION: Addition of 9p21 allele information to CIMT-P minimally improves CHD risk prediction in whites in the ARIC study.
Authors: Alanna C Morrison; Lance A Bare; Lloyd E Chambless; Stephen G Ellis; Mary Malloy; John P Kane; James S Pankow; James J Devlin; James T Willerson; Eric Boerwinkle Journal: Am J Epidemiol Date: 2007-04-18 Impact factor: 4.897
Authors: A D White; A R Folsom; L E Chambless; A R Sharret; K Yang; D Conwill; M Higgins; O D Williams; H A Tyroler Journal: J Clin Epidemiol Date: 1996-02 Impact factor: 6.437
Authors: Thomas J Wang; Philimon Gona; Martin G Larson; Geoffrey H Tofler; Daniel Levy; Christopher Newton-Cheh; Paul F Jacques; Nader Rifai; Jacob Selhub; Sander J Robins; Emelia J Benjamin; Ralph B D'Agostino; Ramachandran S Vasan Journal: N Engl J Med Date: 2006-12-21 Impact factor: 91.245
Authors: Ruth McPherson; Alexander Pertsemlidis; Nihan Kavaslar; Alexandre Stewart; Robert Roberts; David R Cox; David A Hinds; Len A Pennacchio; Anne Tybjaerg-Hansen; Aaron R Folsom; Eric Boerwinkle; Helen H Hobbs; Jonathan C Cohen Journal: Science Date: 2007-05-03 Impact factor: 47.728
Authors: Lloyd E Chambless; Aaron R Folsom; A Richey Sharrett; Paul Sorlie; David Couper; Moyses Szklo; F Javier Nieto Journal: J Clin Epidemiol Date: 2003-09 Impact factor: 6.437
Authors: Heribert Schunkert; Anika Götz; Peter Braund; Ralph McGinnis; David-Alexandre Tregouet; Massimo Mangino; Patrick Linsel-Nitschke; Francois Cambien; Christian Hengstenberg; Klaus Stark; Stefan Blankenberg; Laurence Tiret; Pierre Ducimetiere; Andrew Keniry; Mohammed J R Ghori; Stefan Schreiber; Nour Eddine El Mokhtari; Alistair S Hall; Richard J Dixon; Alison H Goodall; Henrike Liptau; Helen Pollard; Daniel F Schwarz; Ludwig A Hothorn; H-Erich Wichmann; Inke R König; Marcus Fischer; Christa Meisinger; Willem Ouwehand; Panos Deloukas; John R Thompson; Jeanette Erdmann; Andreas Ziegler; Nilesh J Samani Journal: Circulation Date: 2008-03-24 Impact factor: 29.690
Authors: Ariel Brautbar; Lisa A Pompeii; Abbas Dehghan; Julius S Ngwa; Vijay Nambi; Salim S Virani; Fernando Rivadeneira; André G Uitterlinden; Albert Hofman; Jacqueline C M Witteman; Michael J Pencina; Aaron R Folsom; L Adrienne Cupples; Christie M Ballantyne; Eric Boerwinkle Journal: Atherosclerosis Date: 2012-06-12 Impact factor: 5.162
Authors: Anandita Agarwala; Salim Virani; David Couper; Lloyd Chambless; Eric Boerwinkle; Brad C Astor; Ron C Hoogeveen; Joe Coresh; A Richey Sharrett; Aaron R Folsom; Tom Mosley; Christie M Ballantyne; Vijay Nambi Journal: Atherosclerosis Date: 2016-08-25 Impact factor: 5.162
Authors: Christine M Lusk; Greg Dyson; Andrew G Clark; Christie M Ballantyne; Ruth Frikke-Schmidt; Anne Tybjærg-Hansen; Eric Boerwinkle; Charles F Sing Journal: Hum Genet Date: 2014-06-03 Impact factor: 4.132
Authors: Anna Szpakowicz; Witold Pepinski; Ewa Waszkiewicz; Dominika Maciorkowska; Małgorzata Skawronska; Anna Niemcunowicz-Janica; Robert Milewski; Sławomir Dobrzycki; Włodzimierz Jerzy Musial; Karol Adam Kaminski Journal: PLoS One Date: 2013-09-12 Impact factor: 3.240
Authors: Anna Szpakowicz; Marek Kiliszek; Witold Pepinski; Ewa Waszkiewicz; Maria Franaszczyk; Małgorzata Skawronska; Rafal Ploski; Anna Niemcunowicz-Janica; Sławomir Dobrzycki; Grzegorz Opolski; Włodzimierz Jerzy Musial; Karol Adam Kaminski Journal: PLoS One Date: 2014-08-08 Impact factor: 3.240