Anandita Agarwala1, Salim Virani2, David Couper3, Lloyd Chambless3, Eric Boerwinkle4, Brad C Astor5, Ron C Hoogeveen1, Joe Coresh6, A Richey Sharrett6, Aaron R Folsom7, Tom Mosley8, Christie M Ballantyne9, Vijay Nambi10. 1. Baylor College of Medicine, United States. 2. Michael E DeBakey Veterans Affairs Hospital, United States; Methodist DeBakey Heart and Vascular Center, United States. 3. University of North Carolina at Chapel Hill School of Global Public Health, United States. 4. University of Texas, School of Public Health, Houston, United States. 5. University of Wisconsin School of Medicine and Public Health, United States. 6. Johns Hopkins School of Public Health, United States. 7. University of Minnesota, Division of Epidemiology and Community Health, Minneapolis, MN, United States. 8. University of Mississippi, United States. 9. Baylor College of Medicine, United States; Methodist DeBakey Heart and Vascular Center, United States. 10. Michael E DeBakey Veterans Affairs Hospital, United States; Baylor College of Medicine, United States; Methodist DeBakey Heart and Vascular Center, United States. Electronic address: vnambi@bcm.edu.
Abstract
BACKGROUND AND AIMS: Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort. METHODS: 8127 participants from the ARIC study (4th visit, 1996-1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis. RESULTS: While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis. CONCLUSIONS: These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD. Published by Elsevier Ireland Ltd.
BACKGROUND AND AIMS: Biomarkers and atherosclerosis imaging have been studied individually for association with incident cardiovascular disease (CVD); however, limited data exist on whether the biomarkers are associated with events with a similar magnitude in the presence of atherosclerosis. In this study, we assessed whether the presence of atherosclerosis as measured by carotid intima media thickness (cIMT) affects the association between biomarkers known to be associated with coronary heart disease (CHD) and incident cardiovascular disease (CVD) in a primary prevention cohort. METHODS: 8127 participants from the ARIC study (4th visit, 1996-1998) were stratified as having minimal, mild, or substantial atherosclerosis by cIMT. Levels of C-reactive protein, lipoprotein-associated phospholipase A2, cardiac troponin T, N-terminal pro-brain natriuretic peptide, lipoprotein(a), cystatin C, and urine albumin to creatinine ratio were measured in each participant. Hazard ratios were used to determine the relationship between the biomarkers and incident CHD, stroke, and CVD in each category of atherosclerosis. RESULTS: While each of the biomarkers was significantly associated with risk of events overall, we found no significant differences noted in the strength of association of biomarkers with CHD, stroke, and CVD when analyzed by degree of atherosclerosis. CONCLUSIONS: These findings suggest that the level of atherosclerosis does not significantly influence the association between biomarkers and CVD. Published by Elsevier Ireland Ltd.
Entities:
Keywords:
Cardiovascular disease; Carotid intima media thickness; Coronary heart disease; High sensitivity C- reactive protein; High sensitivity troponin T; Lipoprotein associated phospholipase A2; NT-pro B-type natriuretic peptide; Stroke; lipoprotein(a)
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