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Literature DB >> 22343977

Catalytic metallodrugs targeting HCV IRES RNA.

Abstract

A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.

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Year: 2012 PMID： 22343977 DOI： 10.1039/c2cc17377h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

17 in total

1. Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs.

Authors: Kosh P Neupane; Amanda R Aldous; Joshua A Kritzer
Journal: J Inorg Biochem Date: 2014-06-12 Impact factor: 4.155

2. Kinetics and Mechanisms of Oxidative Cleavage of HIV RRE RNA by Rev-Coupled Transition Metal Chelates.

Authors: Jeff C Joyner; Kevin D Keuper; J A Cowan
Journal: Chem Sci Date: 2013-04-01 Impact factor: 9.825

3. Insight into the recognition, binding, and reactivity of catalytic metallodrugs targeting stem loop IIb of hepatitis C IRES RNA.

Authors: Seth S Bradford; Martin James Ross; Insiya Fidai; James A Cowan
Journal: ChemMedChem Date: 2014-04-22 Impact factor: 3.466

4. Analysis of Structure-Activity Relationships Based on the Hepatitis C Virus SLIIb Internal Ribosomal Entry Sequence RNA-Targeting GGHYRFK⋅Cu Complex.

Authors: Martin James Ross; Insiya Fidai; James A Cowan
Journal: Chembiochem Date: 2017-08-07 Impact factor: 3.164

5. Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.

Authors: Zhen Yu; Menglu Han; James A Cowan
Journal: Angew Chem Int Ed Engl Date: 2014-12-11 Impact factor: 15.336

Catalytic metallodrugs targeting HCV IRES RNA.

1. Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs.

2. Kinetics and Mechanisms of Oxidative Cleavage of HIV RRE RNA by Rev-Coupled Transition Metal Chelates.

3. Insight into the recognition, binding, and reactivity of catalytic metallodrugs targeting stem loop IIb of hepatitis C IRES RNA.

4. Analysis of Structure-Activity Relationships Based on the Hepatitis C Virus SLIIb Internal Ribosomal Entry Sequence RNA-Targeting GGHYRFK⋅Cu Complex.

5. Toward the design of a catalytic metallodrug: selective cleavage of G-quadruplex telomeric DNA by an anticancer copper-acridine-ATCUN complex.

6. Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.

7. Inactivation of sortase A mediated by metal ATCUN complexes.

Review 8. Metal complexes promoting catalytic cleavage of nucleic acids-biochemical tools and therapeutics.

Review 9. Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.

10. Catalytic metallodrugs based on the LaR2C peptide target HCV SLIV IRES RNA.