Literature DB >> 22343182

Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes.

Richard Komuniecki1, Wen Jing Law, Aaron Jex, Peter Geldhof, John Gray, Bruce Bamber, Robin B Gasser.   

Abstract

This review is designed to summarize the information on monoamine-dependent paralysis as a target for anthelmintic development, examine the conservation of monoamine receptors in the genomes of both free-living and parasitic nematodes, and highlight the utility of the Caenorhabditis elegans model system for dissecting the monoaminergic modulation of locomotory decision-making. Copyright Â
© 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 22343182      PMCID： PMC3403675          DOI： 10.1016/j.molbiopara.2012.02.001

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  68 in total

1.  Functional characterization of alternatively spliced 5-HT2 receptor isoforms from the pharynx and muscle of the parasitic nematode, Ascaris suum.

Authors:  Xinyan Huang; Hong Xiao; Elizabeth B Rex; Robert J Hobson; William S Messer; Patricia R Komuniecki; Richard W Komuniecki
Journal:  J Neurochem       Date:  2002-10       Impact factor: 5.372

2.  MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.

Authors:  R Ranganathan; S C Cannon; H R Horvitz
Journal:  Nature       Date:  2000-11-23       Impact factor: 49.962

3.  The genetics of ivermectin resistance in Caenorhabditis elegans.

Authors:  J A Dent; M M Smith; D K Vassilatis; L Avery
Journal:  Proc Natl Acad Sci U S A       Date:  2000-03-14       Impact factor: 11.205

Review 4.  Genetic variability following selection of Haemonchus contortus with anthelmintics.

Authors:  R Prichard
Journal:  Trends Parasitol       Date:  2001-09

5.  Changes in locomotory behavior and cAMP produced in Ascaris suum by neuropeptides from Ascaris suum or Caenorhabditis elegans.

Authors:  C A Reinitz; H G Herfel; L A Messinger; A O Stretton
Journal:  Mol Biochem Parasitol       Date:  2000-11       Impact factor: 1.759

Review 6.  Caenorhabditis elegans: how good a model for veterinary parasites?

Authors:  T G Geary; D P Thompson
Journal:  Vet Parasitol       Date:  2001-11-22       Impact factor: 2.738

7.  LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.

Authors:  Ephraim L Tsalik; Timothy Niacaris; Adam S Wenick; Kelvin Pau; Leon Avery; Oliver Hobert
Journal:  Dev Biol       Date:  2003-11-01       Impact factor: 3.582

Review 8.  Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action.

Authors:  Achim Harder; Hans-Peter Schmitt-Wrede; Jürgen Krücken; Predrag Marinovski; Frank Wunderlich; James Willson; Kiran Amliwala; Lindy Holden-Dye; Robert Walker
Journal:  Int J Antimicrob Agents       Date:  2003-09       Impact factor: 5.283

9.  Characterization of a tyramine receptor from Caenorhabditis elegans.

Authors:  Elizabeth Rex; Richard W Komuniecki
Journal:  J Neurochem       Date:  2002-09       Impact factor: 5.372

10.  Characterization of a novel G-protein coupled receptor from the parasitic nematode H. contortus with high affinity for serotonin.

Authors:  Martin W Smith; Tracy L Borts; Renee Emkey; Carolyn A Cook; Christina J Wiggins; Jesus A Gutierrez
Journal:  J Neurochem       Date:  2003-07       Impact factor: 5.372
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  5 in total

1.  Interaction of carvacrol with the Ascaris suum nicotinic acetylcholine receptors and gamma-aminobutyric acid receptors, potential mechanism of antinematodal action.

Authors:  Saša M Trailović; Djordje S Marjanović; Jelena Nedeljković Trailović; Alan P Robertson; Richard J Martin
Journal:  Parasitol Res       Date:  2015-05-07       Impact factor: 2.289

2.  Neuropeptides amplify and focus the monoaminergic inhibition of nociception in Caenorhabditis elegans.

Authors:  Vera Hapiak; Philip Summers; Amanda Ortega; Wen Jing Law; Andrew Stein; Richard Komuniecki
Journal:  J Neurosci       Date:  2013-08-28       Impact factor: 6.167

3.  Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans.

Authors:  Maria Rosa Chitolina Schetinger; Tanara V Peres; Letícia P Arantes; Fabiano Carvalho; Valderi Dressler; Graciela Heidrich; Aaron B Bowman; Michael Aschner
Journal:  Toxicology       Date:  2018-10-15       Impact factor: 4.221

4.  Heterologous Expression in Remodeled C. elegans: A Platform for Monoaminergic Agonist Identification and Anthelmintic Screening.

Authors:  Wenjing Law; Leah M Wuescher; Amanda Ortega; Vera M Hapiak; Patricia R Komuniecki; Richard Komuniecki
Journal:  PLoS Pathog       Date:  2015-04-30       Impact factor: 6.823

5.  Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing.

Authors:  Janis C Weeks; William M Roberts; Caitlyn Leasure; Brian M Suzuki; Kristin J Robinson; Heather Currey; Phurpa Wangchuk; Ramon M Eichenberger; Aleen D Saxton; Thomas D Bird; Brian C Kraemer; Alex Loukas; John M Hawdon; Conor R Caffrey; Nicole F Liachko
Journal:  Sci Rep       Date:  2018-01-17       Impact factor: 4.379
  5 in total

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