| Literature DB >> 11530357 |
Abstract
Genetic diversity in nematodes leads to variation in response to anthelmintics. Haemonchus contortus shows enormous genetic diversity, allowing anthelmintic resistance alleles to be rapidly selected. Anthelmintic resistance is now a widespread problem, especially in H. contortus. Here, I compare the genes involved in anthelmintic resistance in H. contortus with those that confer susceptibility or resistance on the free living nematode Caenorhabditis elegans. I also discuss the latest knowledge of genes associated with resistance to benzimidazoles, levamisole and the macrocyclic lactones and the need for DNA markers for anthelmintic resistance.Entities:
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Year: 2001 PMID: 11530357 DOI: 10.1016/s1471-4922(01)01983-3
Source DB: PubMed Journal: Trends Parasitol ISSN: 1471-4922