In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an "ideal" drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed.
In this review we put the spotlight on crosslinked pan class="Chemical">polymer nanogels, a promising platform that has the characteristics of an "ideal" drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed.
Authors: Ja-Hyoung Ryu; Reuben T Chacko; Siriporn Jiwpanich; Sean Bickerton; R Prakash Babu; S Thayumanavan Journal: J Am Chem Soc Date: 2010-11-15 Impact factor: 15.419
Authors: Mark E Davis; Jonathan E Zuckerman; Chung Hang J Choi; David Seligson; Anthony Tolcher; Christopher A Alabi; Yun Yen; Jeremy D Heidel; Antoni Ribas Journal: Nature Date: 2010-03-21 Impact factor: 49.962
Authors: Jong Oh Kim; Hardeep S Oberoi; Swapnil Desale; Alexander V Kabanov; Tatiana K Bronich Journal: J Drug Target Date: 2013-09-02 Impact factor: 5.121
Authors: James I Griffin; Siu Kit Kevin Cheng; Tomoko Hayashi; Dennis Carson; Manju Saraswathy; Devatha P Nair; Dmitri Simberg Journal: Nanomedicine Date: 2017-04-17 Impact factor: 5.307
Authors: Natalia V Nukolova; Hardeep S Oberoi; Yi Zhao; Vladimir P Chekhonin; Alexander V Kabanov; Tatiana K Bronich Journal: Mol Pharm Date: 2013-08-30 Impact factor: 4.939