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Literature DB >> 32721561

Biodegradable cationic nanogels with tunable size, swelling and pK_a for drug delivery.

D S Spencer¹, A B Shodeinde¹, D W Beckman², B C Luu³, H R Hodges³, N A Peppas⁴.

Abstract

Cationic polymers have garnered significant interest for their utility in intracellular drug delivery and gene therapy. However, due to their associated toxicities, novel synthesis approaches must be explored to develop materials that are biocompatible. The novel library of nanoparticles synthesized in this study exhibit tunable hydrodynamic diameters, composition and pH-responsive properties as a function of synthesis parameters. In addition, differences in the responsiveness of these nanoparticles under different pH conditions affords greater control over intracellular drug release.

Entities: Disease

Keywords: ATRP; Drug delivery; Hydrogels; Miniemulsion polymerization; Nanoparticles; pH-responsive

Year: 2020 PMID： 32721561 PMCID： PMC7541487 DOI： 10.1016/j.ijpharm.2020.119691

Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875

29 in total

1. Development of pH sensitive 2-(diisopropylamino)ethyl methacrylate based nanoparticles for photodynamic therapy.

Authors: Cheng-Liang Peng; Li-Yuan Yang; Tsai-Yueh Luo; Ping-Shan Lai; Shu-Jyuan Yang; Wuu-Jyh Lin; Ming-Jium Shieh
Journal: Nanotechnology Date: 2010-03-23 Impact factor: 3.874

2. Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery.

Authors: D C Forbes; M Creixell; H Frizzell; N A Peppas
Journal: Eur J Pharm Biopharm Date: 2013-02-06 Impact factor: 5.571

3. Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment.

Authors: David S Spencer; Amey S Puranik; Nicholas A Peppas
Journal: Curr Opin Chem Eng Date: 2015-02 Impact factor: 5.163

4. Diminishing catalyst concentration in atom transfer radical polymerization with reducing agents.

Authors: Krzysztof Matyjaszewski; Wojciech Jakubowski; Ke Min; Wei Tang; Jinyu Huang; Wade A Braunecker; Nicolay V Tsarevsky
Journal: Proc Natl Acad Sci U S A Date: 2006-10-10 Impact factor: 11.205

5. Control of Cationic Nanogel PEGylation in Heterogeneous ARGET ATRP Emulsion Polymerization with PEG Macromonomers.

Authors: David S Spencer; Bryan C Luu; David W Beckman; Nicholas A Peppas
Journal: J Polym Sci A Polym Chem Date: 2018-05-07 Impact factor: 2.702

Review 6. Tumor pH and its measurement.

Authors: Xiaomeng Zhang; Yuxiang Lin; Robert J Gillies
Journal: J Nucl Med Date: 2010-07-21 Impact factor: 10.057

7. Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery.

Authors: Hongmei Li; Shann S Yu; Martina Miteva; Christopher E Nelson; Thomas Werfel; Todd D Giorgio; Craig L Duvall
Journal: Adv Funct Mater Date: 2013-06-25 Impact factor: 18.808

8. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

Authors: Akin Akinc; Andreas Zumbuehl; Michael Goldberg; Elizaveta S Leshchiner; Valentina Busini; Naushad Hossain; Sergio A Bacallado; David N Nguyen; Jason Fuller; Rene Alvarez; Anna Borodovsky; Todd Borland; Rainer Constien; Antonin de Fougerolles; J Robert Dorkin; K Narayanannair Jayaprakash; Muthusamy Jayaraman; Matthias John; Victor Koteliansky; Muthiah Manoharan; Lubomir Nechev; June Qin; Timothy Racie; Denitza Raitcheva; Kallanthottathil G Rajeev; Dinah W Y Sah; Jürgen Soutschek; Ivanka Toudjarska; Hans-Peter Vornlocher; Tracy S Zimmermann; Robert Langer; Daniel G Anderson
Journal: Nat Biotechnol Date: 2008-04-27 Impact factor: 54.908

Biodegradable cationic nanogels with tunable size, swelling and pK_a for drug delivery.

1. Development of pH sensitive 2-(diisopropylamino)ethyl methacrylate based nanoparticles for photodynamic therapy.

2. Polycationic nanoparticles synthesized using ARGET ATRP for drug delivery.

3. Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment.

4. Diminishing catalyst concentration in atom transfer radical polymerization with reducing agents.

5. Control of Cationic Nanogel PEGylation in Heterogeneous ARGET ATRP Emulsion Polymerization with PEG Macromonomers.

Review 6. Tumor pH and its measurement.

7. Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery.

8. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics.

9. Enhanced core hydrophobicity, functionalization and cell penetration of polybasic nanomatrices.

10. Principles of nanoparticle design for overcoming biological barriers to drug delivery.

1. Cytocompatibility, membrane disruption, and siRNA delivery using environmentally responsive cationic nanogels.

Review 2. Advanced biomedical hydrogels: molecular architecture and its impact on medical applications.