Literature DB >> 22342169

The role of STAT5 in lymphocyte development and transformation.

Lynn M Heltemes-Harris1, Michael A Farrar.   

Abstract

STAT5 plays a crucial role in B and T lymphocyte development. However, whether STAT5 primarily plays a role as a permissive factor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiation, has been unclear. In addition, while STAT5 has been suggested to act as a transcriptional repressor, the mechanism by which it represses transcription was undefined. Recent reports have begun to shed new light on these roles for STAT5 in lymphocyte development, transcriptional repression, and leukemic transformation.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22342169      PMCID： PMC3319496          DOI： 10.1016/j.coi.2012.01.015

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  46 in total

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Journal:  Methods Enzymol       Date:  2010       Impact factor: 1.600

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5.  BCL6 is critical for the development of a diverse primary B cell repertoire.

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9.  Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.

Authors:  Lynn M Heltemes-Harris; Mark J L Willette; Laura B Ramsey; Yi Hua Qiu; E Shannon Neeley; Nianxiang Zhang; Deborah A Thomas; Thearith Koeuth; Emily C Baechler; Steven M Kornblau; Michael A Farrar
Journal:  J Exp Med       Date:  2011-05-23       Impact factor: 14.307

10.  Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.

Authors:  Ye Zheng; Steven Josefowicz; Ashutosh Chaudhry; Xiao P Peng; Katherine Forbush; Alexander Y Rudensky
Journal:  Nature       Date:  2010-01-13       Impact factor: 49.962
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  32 in total

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Review 2.  Manipulation of the innate immune response by human papillomaviruses.

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Journal:  Virus Res       Date:  2016-11-05       Impact factor: 3.303

Review 3.  DNA damage response is hijacked by human papillomaviruses to complete their life cycle.

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4.  Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway.

Authors:  P P Piccaluga; M Rossi; C Agostinelli; F Ricci; A Gazzola; S Righi; F Fuligni; M A Laginestra; M Mancini; M R Sapienza; A De Renzo; P L Tazzari; D Gibellini; P Went; F Alviano; P L Zinzani; G P Bagnara; G Inghirami; C Tripodo; S A Pileri
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5.  STAT-5 is activated constitutively in T cells, B cells and monocytes from patients with primary Sjögren's syndrome.

Authors:  M Pertovaara; O Silvennoinen; P Isomäki
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6.  Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.

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Review 7.  Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology.

Authors:  Carlota Recio; Borja Guerra; Miguel Guerra-Rodríguez; Haidée Aranda-Tavío; Patricia Martín-Rodríguez; Mercedes de Mirecki-Garrido; Yeray Brito-Casillas; José M García-Castellano; Ana Estévez-Braun; Leandro Fernández-Pérez
Journal:  Oncogene       Date:  2019-02-19       Impact factor: 9.867

8.  Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3.

Authors:  Grace Lin; Christopher R LaPensee; Zhaohui S Qin; Jessica Schwartz
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9.  Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas.

Authors:  A Nicolae; L Xi; S Pittaluga; Z Abdullaev; S D Pack; J Chen; T A Waldmann; E S Jaffe; M Raffeld
Journal:  Leukemia       Date:  2014-06-20       Impact factor: 11.528

10.  Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development.

Authors:  Tomohiro Miyai; Shintaro Hojyo; Tomokatsu Ikawa; Masami Kawamura; Tarou Irié; Hideki Ogura; Atsushi Hijikata; Bum-Ho Bin; Takuwa Yasuda; Hiroshi Kitamura; Manabu Nakayama; Osamu Ohara; Hisahiro Yoshida; Haruhiko Koseki; Kenji Mishima; Toshiyuki Fukada
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-29       Impact factor: 11.205
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