Literature DB >> 223367

Growth of the WW strain of Theiler virus in mouse central nervous system organotypic culture.

Z Wroblewska, S U Kim, W D Sheffield, D H Gilden.   

Abstract

Myelinated organotypic cultures of mouse central nervous system (CNS) provide a favorable milieu for growth of the WW strain of Theiler virus (TV). WW-TV induced a cytopathic effect characterized by neuronal destruction and swelling of myelin sheaths. Tissue culture medium and homogenates of infected cultures produced neurologic disease in mice, and TV was demonstrated in cultures by indirect immunofluorescence and electron microscopy. Ultrastructurally, severe alterations in neurons and the presence of cytoplasmic inclusions containing paracrystalline arrays of 30-nm virus particles were evident in astrocytes. Demyelination appeared to be secondary to lysis of oligodendrocytes by virus. CNS organotypic cultures provide an environment for the study of TV-induced demyelination.

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Year:  1979        PMID： 223367     DOI： 10.1007/bf00698267

Source DB:  PubMed          Journal:  Acta Neuropathol        ISSN： 0001-6322            Impact factor:   17.088


  13 in total

1.  Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes.

Authors:  M B BORNSTEIN
Journal:  Lab Invest       Date:  1958 Mar-Apr       Impact factor: 5.662

2.  Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination.

Authors:  H L Lipton
Journal:  Infect Immun       Date:  1975-05       Impact factor: 3.441

3.  Ultrastructure of mumps virus replication in organotypic cultures of hamster choroid plexus.

Authors:  J S Wolinsky; J M Kelly; J R Baringer
Journal:  J Gen Virol       Date:  1976-02       Impact factor: 3.891

4.  Virus-specific intracytoplasmic inclusions in mouse brain produced by a newly isolated strain of Theiler virus. I. Virologic and morphologic studies.

Authors:  Z Wroblewska; D H Gilden; M Wellish; L B Rorke; K G Warren; J S Wolinsky
Journal:  Lab Invest       Date:  1977-12       Impact factor: 5.662

5.  Herpes virus hominis type 2 and intranuclear tubular structures in organized nervous tissue cultures.

Authors:  M Dubois-Dalcq; M Buyse; N Lefebvre; S Sprecher-Goldberger
Journal:  Acta Neuropathol       Date:  1972       Impact factor: 17.088

6.  Morphological and biochemical development of chick cerebrum cultured in vitro.

Authors:  S U Kim; G Tunnicliff
Journal:  Exp Neurol       Date:  1974-06       Impact factor: 5.330

7.  Experimental panencephalitis induced in suckling mice, by parainfluenza type 1 (6/94) virus, II. Virologic studies.

Authors:  D H Gilden; Z Wroblewska; M Chesler; M C Wellish; F S Lief; J S Wolinsky; L B Rorke
Journal:  J Neuropathol Exp Neurol       Date:  1976-05       Impact factor: 3.685

8.  Theiler's virus-induced demyelination: prevention by immunosuppression.

Authors:  H L Lipton; M C Dal Canto
Journal:  Science       Date:  1976-04-02       Impact factor: 47.728

9.  Demyelinative myelopathy in mice induced by the DA virus.

Authors:  J R Lehrich; B G Arnason; F H Hochberg
Journal:  J Neurol Sci       Date:  1976-10       Impact factor: 3.181

10.  SPONTANEOUS ENCEPHALOMYELITIS OF MICE, A NEW VIRUS DISEASE.

Authors:  M Theiler
Journal:  J Exp Med       Date:  1937-04-30       Impact factor: 14.307
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  7 in total

1.  The neurovirulence of the DA and GDVII strains of Theiler's virus correlates with their ability To infect cultured neurons.

Authors:  N Jarousse; S Syan; C Martinat; M Brahic
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

Review 2.  Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis.

Authors:  Ikuo Tsunoda; Robert S Fujinami
Journal:  J Neuroimmune Pharmacol       Date:  2009-11-06       Impact factor: 4.147

3.  Uncoupled relationship between demyelination and primary infection of myelinating cells in Theiler's virus encephalomyelitis.

Authors:  M C Dal Canto
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

4.  CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis.

Authors:  P D Murray; K D Pavelko; J Leibowitz; X Lin; M Rodriguez
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

Review 5.  Pathogenesis of Theiler's murine encephalomyelitis virus.

Authors:  M Yamada; A Zurbriggen; R S Fujinami
Journal:  Adv Virus Res       Date:  1991       Impact factor: 9.937

Review 6.  Mechanisms of virus-induced demyelination and remyelination.

Authors:  M Rodriguez
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

Review 7.  Pathogenesis of virus-induced demyelination.

Authors:  J K Fazakerley; M J Buchmeier
Journal:  Adv Virus Res       Date:  1993       Impact factor: 9.937
  7 in total

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