Literature DB >> 22331622

Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes.

Alexia Eliades1, Shinobu Matsuura, Katya Ravid.   

Abstract

Reactive oxygen species (ROS), generated as a result of various reactions, control an array of cellular processes. The role of ROS during megakaryocyte (MK) development has been a subject of interest and research. The bone marrow niche is a site of MK differentiation and maturation. In this environment, a gradient of oxygen tension, from normoxia to hypoxia results in different levels of ROS, impacting cellular physiology. This article provides an overview of major sources of ROS, their implication in different signaling pathways, and their effect on cellular physiology, with a focus on megakaryopoiesis. The importance of ROS-generating oxidases in MK biology and pathology, including myelofibrosis, is also described.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID: 22331622      PMCID: PMC3357446          DOI: 10.1002/jcp.24071

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN: 0021-9541            Impact factor:   6.384


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