BACKGROUND AND PURPOSE: Familial transmission of stroke and myocardial infarction (MI) is partially mediated by transmission of cerebrovascular and cardiovascular risk factors. We examined relationships between family risk of stroke and MI with risk factors for these phenotypes. METHODS: A cross-sectional association between the stratified log-rank family score for stroke and MI with prevalent risk factors was assessed in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. RESULTS: Individuals in the fourth quartile of stratified log-rank family scores for stroke were more likely to have prevalent risk factors including hypertension (OR, 1.43; 95% CI, 1.30-1.58), left ventricular hypertrophy (OR, 1.42; 95% CI, 1.16-1.42), diabetes (OR, 1.26; 95% CI, 1.12-1.43), and atrial fibrillation (OR, 1.23; 95% CI, 1.03-1.45) compared with individuals in the first quartile. Likewise, individuals in the fourth quartile of stratified log-rank family scores for MI were more likely to have prevalent risk factors including hypertension (OR, 1.57; 95% CI, 1.27-1.94) and diabetes (OR, 1.29; 95% CI, 1.12-1.43) than the first quartile. In contrast to stroke, the family risk score for MI was associated with dyslipidemia (OR, 1.38; 95% CI, 1.23-1.55) and overweight/obesity (OR, 1.22; 95% CI, 1.10-1.37). CONCLUSIONS: Family risk of stroke and MI is strongly associated with the majority of risk factors associated with each disease. Family history and genetic studies separating nonspecific contributions of intermediate phenotypes from specific contributions to the disease phenotype may lead to a more thorough understanding of transmission for these complex disorders.
BACKGROUND AND PURPOSE: Familial transmission of stroke and myocardial infarction (MI) is partially mediated by transmission of cerebrovascular and cardiovascular risk factors. We examined relationships between family risk of stroke and MI with risk factors for these phenotypes. METHODS: A cross-sectional association between the stratified log-rank family score for stroke and MI with prevalent risk factors was assessed in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort. RESULTS: Individuals in the fourth quartile of stratified log-rank family scores for stroke were more likely to have prevalent risk factors including hypertension (OR, 1.43; 95% CI, 1.30-1.58), left ventricular hypertrophy (OR, 1.42; 95% CI, 1.16-1.42), diabetes (OR, 1.26; 95% CI, 1.12-1.43), and atrial fibrillation (OR, 1.23; 95% CI, 1.03-1.45) compared with individuals in the first quartile. Likewise, individuals in the fourth quartile of stratified log-rank family scores for MI were more likely to have prevalent risk factors including hypertension (OR, 1.57; 95% CI, 1.27-1.94) and diabetes (OR, 1.29; 95% CI, 1.12-1.43) than the first quartile. In contrast to stroke, the family risk score for MI was associated with dyslipidemia (OR, 1.38; 95% CI, 1.23-1.55) and overweight/obesity (OR, 1.22; 95% CI, 1.10-1.37). CONCLUSIONS: Family risk of stroke and MI is strongly associated with the majority of risk factors associated with each disease. Family history and genetic studies separating nonspecific contributions of intermediate phenotypes from specific contributions to the disease phenotype may lead to a more thorough understanding of transmission for these complex disorders.
Authors: Ulrich Broeckel; Christian Hengstenberg; Björn Mayer; Stephan Holmer; Lisa J Martin; Anthony G Comuzzie; John Blangero; Peter Nürnberg; André Reis; Günter A J Riegger; Howard J Jacob; Heribert Schunkert Journal: Nat Genet Date: 2002-01-30 Impact factor: 38.330
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Authors: Caroline S Fox; Joseph F Polak; Irmarie Chazaro; Adrienne Cupples; Philip A Wolf; Ralph A D'Agostino; Christopher J O'Donnell Journal: Stroke Date: 2003-02 Impact factor: 7.914
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Authors: James N Kiage; Peter D Merrill; Cody J Robinson; Yue Cao; Talha A Malik; Barrett C Hundley; Ping Lao; Suzanne E Judd; Mary Cushman; Virginia J Howard; Edmond K Kabagambe Journal: Am J Clin Nutr Date: 2013-04-03 Impact factor: 7.045
Authors: Beatriz Maria Pereira Girolineto; Alan Maicon de Oliveira; Ana Maria Rosa Freato Gonçalves; Marília Silveira de Almeida Campos; Leonardo Régis Leira Pereira Journal: Einstein (Sao Paulo) Date: 2019-12-13
Authors: Xueyan Zhao; Xin Geng; Vinodh Srinivasasainagendra; Ninad Chaudhary; Suzanne Judd; Virginia Wadley; Orlando M Gutiérrez; Henry Wang; Ethan M Lange; Leslie A Lange; Daniel Woo; Frederick W Unverzagt; Monika Safford; Mary Cushman; Nita Limdi; Rakale Quarells; Donna K Arnett; Marguerite R Irvin; Degui Zhi Journal: BMC Med Genomics Date: 2019-01-31 Impact factor: 3.063