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Literature DB >> 22328135

Functional heterogeneity of arcuate nucleus pro-opiomelanocortin neurons: implications for diverging melanocortin pathways.

Abstract

Arcuate nucleus (ARC) pro-opiomelanocortin (POMC) neurons are essential regulators of food intake, energy expenditure, and glucose homeostasis. POMC neurons integrate several key metabolic signals that include neurotransmitters and hormones. The change in activity of POMC neurons is relayed to melanocortin receptors in distinct regions of the central nervous system. This review will summarize the role of leptin and serotonin receptors in regulating the activity of POMC neurons and provide a model in which different melanocortin pathways regulate energy and glucose homeostasis.

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Year: 2012 PMID： 22328135 PMCID： PMC3755591 DOI： 10.1007/s12035-012-8240-6

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

92 in total

1. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Authors: Jong-Woo Sohn; Yong Xu; Juli E Jones; Kevin Wickman; Kevin W Williams; Joel K Elmquist
Journal: Neuron Date: 2011-08-11 Impact factor: 17.173

2. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis.

Authors: Jari Rossi; Nina Balthasar; David Olson; Michael Scott; Eric Berglund; Charlotte E Lee; Michelle J Choi; Danielle Lauzon; Bradford B Lowell; Joel K Elmquist
Journal: Cell Metab Date: 2011-02-02 Impact factor: 27.287

3. Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus.

Authors: D S Ludwig; K G Mountjoy; J B Tatro; J A Gillette; R C Frederich; J S Flier; E Maratos-Flier
Journal: Am J Physiol Date: 1998-04

4. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.

Authors: Linh Vong; Chianping Ye; Zongfang Yang; Brian Choi; Streamson Chua; Bradford B Lowell
Journal: Neuron Date: 2011-07-14 Impact factor: 17.173

5. Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice.

Authors: Michael M Scott; Kevin W Williams; Jari Rossi; Charlotte E Lee; Joel K Elmquist
Journal: J Clin Invest Date: 2011-05-23 Impact factor: 14.808

6. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

Authors: Michael J Krashes; Shuichi Koda; ChianPing Ye; Sarah C Rogan; Andrew C Adams; Daniel S Cusher; Eleftheria Maratos-Flier; Bryan L Roth; Bradford B Lowell
Journal: J Clin Invest Date: 2011-04 Impact factor: 14.808

7. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin.

Authors: T M Mizuno; S P Kleopoulos; H T Bergen; J L Roberts; C A Priest; C V Mobbs
Journal: Diabetes Date: 1998-02 Impact factor: 9.461

Review 8. Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network.

Authors: Kevin W Williams; Michael M Scott; Joel K Elmquist
Journal: Eur J Pharmacol Date: 2011-01-03 Impact factor: 4.432

9. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels.

Authors: D Spanswick; M A Smith; V E Groppi; S D Logan; M L Ashford
Journal: Nature Date: 1997-12-04 Impact factor: 49.962

10. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.

Authors: Yexica Aponte; Deniz Atasoy; Scott M Sternson
Journal: Nat Neurosci Date: 2010-01-05 Impact factor: 24.884

22 in total

Review 1. Participation of the central melanocortin system in metabolic regulation and energy homeostasis.

Authors: Jin Kwon Jeong; Jae Geun Kim; Byung Ju Lee
Journal: Cell Mol Life Sci Date: 2014-06-04 Impact factor: 9.261

2. Beta-endorphin cell therapy for cancer prevention.

Authors: Changqing Zhang; Sengottuvelan Murugan; Nadka Boyadjieva; Shaima Jabbar; Pallavi Shrivastava; Dipak K Sarkar
Journal: Cancer Prev Res (Phila) Date: 2014-11-17

Review 3. The melanocortin pathway and control of appetite-progress and therapeutic implications.

Authors: Giulia Baldini; Kevin D Phelan
Journal: J Endocrinol Date: 2019-04-01 Impact factor: 4.286

Review 4. Neuronal circuits that regulate feeding behavior and metabolism.

Authors: Jong-Woo Sohn; Joel K Elmquist; Kevin W Williams
Journal: Trends Neurosci Date: 2013-06-19 Impact factor: 13.837

5. Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A.

Authors: Kristy L Townsend; Christopher J Madden; Magdalena Blaszkiewicz; Lindsay McDougall; Domenico Tupone; Matthew D Lynes; Yuji Mishina; Paul Yu; Shaun F Morrison; Yu-Hua Tseng
Journal: Endocrinology Date: 2017-12-01 Impact factor: 4.736

6. Fluoxetine Modulates the Activity of Hypothalamic POMC Neurons via mTOR Signaling.

Authors: Ilaria Barone; Riccardo Melani; Marco Mainardi; Gaia Scabia; Manuela Scali; Alessia Dattilo; Giovanni Ceccarini; Paolo Vitti; Ferruccio Santini; Lamberto Maffei; Tommaso Pizzorusso; Margherita Maffei
Journal: Mol Neurobiol Date: 2018-04-16 Impact factor: 5.590