Literature DB >> 21835345

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Jong-Woo Sohn1, Yong Xu, Juli E Jones, Kevin Wickman, Kevin W Williams, Joel K Elmquist.   

Abstract

VIDEO ABSTRACT: Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a 5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21835345      PMCID： PMC3184528          DOI： 10.1016/j.neuron.2011.06.012

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  47 in total

1.  Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.

Authors:  Dzwokai Ma; Noa Zerangue; Kimberly Raab-Graham; Sharon R Fried; Yuh Nung Jan; Lily Yeh Jan
Journal:  Neuron       Date:  2002-02-28       Impact factor: 17.173

Review 2.  The TRPC3/6/7 subfamily of cation channels.

Authors:  Mohamed Trebak; Guillermo Vazquez; Gary St J Bird; James W Putney
Journal:  Cell Calcium       Date:  2003 May-Jun       Impact factor: 6.817

Review 3.  Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems.

Authors:  Marco Giorgetti; Laurence H Tecott
Journal:  Eur J Pharmacol       Date:  2004-03-19       Impact factor: 4.432

4.  TRPC1 and TRPC5 form a novel cation channel in mammalian brain.

Authors:  C Strübing; G Krapivinsky; L Krapivinsky; D E Clapham
Journal:  Neuron       Date:  2001-03       Impact factor: 17.173

Review 5.  The TRP ion channel family.

Authors:  D E Clapham; L W Runnels; C Strübing
Journal:  Nat Rev Neurosci       Date:  2001-06       Impact factor: 34.870

6.  D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons.

Authors:  Viviana Davila; Zhen Yan; Liviu C Craciun; Diomedes Logothetis; David Sulzer
Journal:  J Neurosci       Date:  2003-07-02       Impact factor: 6.167

7.  Activation of central melanocortin pathways by fenfluramine.

Authors:  Lora K Heisler; Michael A Cowley; Laurence H Tecott; Wei Fan; Malcolm J Low; James L Smart; Marcelo Rubinstein; Jeffrey B Tatro; Jacob N Marcus; Henne Holstege; Charlotte E Lee; Roger D Cone; Joel K Elmquist
Journal:  Science       Date:  2002-07-26       Impact factor: 47.728

Review 8.  Central serotonin and melanocortin pathways regulating energy homeostasis.

Authors:  Lora K Heisler; Michael A Cowley; Toshiro Kishi; Laurence H Tecott; Wei Fan; Malcolm J Low; James L Smart; Marcelo Rubinstein; Jeffrey B Tatro; Jeffrey M Zigman; Roger D Cone; Joel K Elmquist
Journal:  Ann N Y Acad Sci       Date:  2003-06       Impact factor: 5.691

9.  Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system.

Authors:  Hans G Cruz; Tatiana Ivanova; Marie-Louise Lunn; Markus Stoffel; Paul A Slesinger; Christian Lüscher
Journal:  Nat Neurosci       Date:  2004-01-25       Impact factor: 24.884

10.  5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Authors:  Yong Xu; Eric D Berglund; Jong-Woo Sohn; William L Holland; Jen-Chieh Chuang; Makoto Fukuda; Jari Rossi; Kevin W Williams; Juli E Jones; Jeffrey M Zigman; Bradford B Lowell; Philipp E Scherer; Joel K Elmquist
Journal:  Nat Neurosci       Date:  2010-10-31       Impact factor: 24.884
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  94 in total

1.  Role of neuronal nitric oxide synthase in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis.

Authors:  Amanda Borgquist; Cecilia Meza; Edward J Wagner
Journal:  J Neurophysiol       Date:  2014-11-12       Impact factor: 2.714

Review 2.  Selective leptin resistance revisited.

Authors:  Allyn L Mark
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-07-24       Impact factor: 3.619

Review 3.  Brain regulation of energy balance and body weight.

Authors:  Liangyou Rui
Journal:  Rev Endocr Metab Disord       Date:  2013-12       Impact factor: 6.514

Review 4.  TRPCing around the hypothalamus.

Authors:  Martin J Kelly; Jian Qiu; Oline K Rønnekleiv
Journal:  Front Neuroendocrinol       Date:  2018-05-31       Impact factor: 8.606

Review 5.  POMC Neurons: From Birth to Death.

Authors:  Chitoku Toda; Anna Santoro; Jung Dae Kim; Sabrina Diano
Journal:  Annu Rev Physiol       Date:  2017-02-10       Impact factor: 19.318

6.  Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis.

Authors:  Eric D Berglund; Chen Liu; Jong-Woo Sohn; Tiemin Liu; Mi Hwa Kim; Charlotte E Lee; Claudia R Vianna; Kevin W Williams; Yong Xu; Joel K Elmquist
Journal:  J Clin Invest       Date:  2013-11-01       Impact factor: 14.808

Review 7.  Melanocortin neurons: Multiple routes to regulation of metabolism.

Authors:  Wen-Jie Shen; Ting Yao; Xingxing Kong; Kevin W Williams; Tiemin Liu
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-05-09       Impact factor: 5.187

8.  Alpha2delta-1 in SF1+ Neurons of the Ventromedial Hypothalamus Is an Essential Regulator of Glucose and Lipid Homeostasis.

Authors:  Jennifer A Felsted; Cheng-Hao Chien; Dongqing Wang; Micaella Panessiti; Dominique Ameroso; Andrew Greenberg; Guoping Feng; Dong Kong; Maribel Rios
Journal:  Cell Rep       Date:  2017-12-05       Impact factor: 9.423

9.  The Leptin, Dopamine and Serotonin Receptors in Hypothalamic POMC-Neurons of Normal and Obese Rodents.

Authors:  Irina V Romanova; Kira V Derkach; Anastasiya L Mikhrina; Ivan B Sukhov; Elena V Mikhailova; Alexander O Shpakov
Journal:  Neurochem Res       Date:  2018-02-03       Impact factor: 3.996

10.  Disruption of GABA or glutamate release from POMC neurons in the adult mouse does not affect metabolic end points.

Authors:  Andrew R Rau; Connie M King; Shane T Hentges
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-09-16       Impact factor: 3.619
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