| Literature DB >> 22326396 |
Keith W Woods1, Chunqiu Lai, Julie M Miyashiro, Yunsong Tong, Alan S Florjancic, Edward K Han, Niru Soni, Yan Shi, Loren Lasko, Joel D Leverson, Eric F Johnson, Alexander R Shoemaker, Thomas D Penning.
Abstract
We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K(i)) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds to inhibition of MCM2 phosphorylation.Entities:
Mesh：
Substances：
Year: 2012 PMID： 22326396 DOI： 10.1016/j.bmcl.2012.01.041
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823