Literature DB >> 22325376

Fetal surgery for myelomeningocele: trials and tribulations. Isabella Forshall Lecture.

N Scott Adzick1.   

Abstract

The rationale for in utero repair of myelomeningocele (MMC) in the context of pathologic observations, animal models, and outcomes from the initial experience with human fetal MMC repair is presented. This has now culminated in a randomized trial, Management of Myelomeningocele Study, the findings of which are listed. The story is focused on the milestone contributions of members of the Center for Fetal Diagnosis and Treatment at the Children's Hospital of Philadelphia on the road to successful fetal surgery for spina bifida. This is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC.
Copyright © 2012 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Year:  2012        PMID： 22325376      PMCID： PMC3278714          DOI： 10.1016/j.jpedsurg.2011.11.021

Source DB:  PubMed          Journal:  J Pediatr Surg        ISSN： 0022-3468            Impact factor:   2.545


  58 in total

1.  Long-term outcome in open spina bifida.

Authors:  Pippa Oakeshott; Gillian M Hunt
Journal:  Br J Gen Pract       Date:  2003-08       Impact factor: 5.386

2.  Fetal myelomeningocele repair: short-term clinical outcomes.

Authors:  Mark P Johnson; Leslie N Sutton; Natalie Rintoul; Timothy M Crombleholme; Alan W Flake; Lori J Howell; Holly L Hedrick; R Douglas Wilson; N Scott Adzick
Journal:  Am J Obstet Gynecol       Date:  2003-08       Impact factor: 8.661

Review 3.  Neural-tube defects.

Authors:  L D Botto; C A Moore; M J Khoury; J D Erickson
Journal:  N Engl J Med       Date:  1999-11-11       Impact factor: 91.245

4.  The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus.

Authors:  Noel Tulipan; Leslie N Sutton; Joseph P Bruner; Brian M Cohen; Mark Johnson; N Scott Adzick
Journal:  Pediatr Neurosurg       Date:  2003-01       Impact factor: 1.162

5.  Improvement in hindbrain herniation demonstrated by serial fetal magnetic resonance imaging following fetal surgery for myelomeningocele.

Authors:  L N Sutton; N S Adzick; L T Bilaniuk; M P Johnson; T M Crombleholme; A W Flake
Journal:  JAMA       Date:  1999-11-17       Impact factor: 56.272

6.  Hindbrain herniation develops in surgically created myelomeningocele but is absent after repair in fetal lambs.

Authors:  B W Paek; D L Farmer; C C Wilkinson; C T Albanese; W Peacock; M R Harrison; R W Jennings
Journal:  Am J Obstet Gynecol       Date:  2000-11       Impact factor: 8.661

7.  A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention.

Authors:  Natalie E Rintoul; Leslie N Sutton; Anne M Hubbard; Brian Cohen; Jeanne Melchionni; Patrick S Pasquariello; N Scott Adzick
Journal:  Pediatrics       Date:  2002-03       Impact factor: 7.124

8.  In utero repair of myelomeningocele: experimental pathophysiology, initial clinical experience, and outcomes.

Authors:  Diana L Farmer; Cornelia S von Koch; Warwick J Peacock; Moise Danielpour; Nalin Gupta; Hanmin Lee; Michael R Harrison
Journal:  Arch Surg       Date:  2003-08

9.  Epidemiologic characteristics of phenotypically distinct neural tube defects among 0.7 million California births, 1983-1987.

Authors:  G M Shaw; N G Jensvold; C R Wasserman; E J Lammer
Journal:  Teratology       Date:  1994-02

10.  Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep.

Authors:  Sarah Bouchard; Marcus G Davey; Natalie E Rintoul; Danielle S Walsh; Lucy B Rorke; N Scott Adzick
Journal:  J Pediatr Surg       Date:  2003-03       Impact factor: 2.545
View more
  14 in total

1.  Physician views regarding the benefits and burdens of prenatal surgery for myelomeningocele.

Authors:  R M Antiel; C A Collura; A W Flake; M P Johnson; N E Rintoul; J D Lantos; F A Curlin; J C Tilburt; S D Brown; C Feudtner
Journal:  J Perinatol       Date:  2017-06-15       Impact factor: 2.521

Review 2.  Imaging of open spinal dysraphisms in the era of prenatal surgery.

Authors:  Usha D Nagaraj; Beth M Kline-Fath
Journal:  Pediatr Radiol       Date:  2020-11-30

3.  Mutations in folate transporter genes and risk for human myelomeningocele.

Authors:  Tina O Findley; Joy C Tenpenny; Michelle R O'Byrne; Alanna C Morrison; James E Hixson; Hope Northrup; Kit Sing Au
Journal:  Am J Med Genet A       Date:  2017-09-26       Impact factor: 2.802

4.  Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele.

Authors:  Aijun Wang; Erin G Brown; Lee Lankford; Benjamin A Keller; Christopher D Pivetti; Nicole A Sitkin; Michael S Beattie; Jacqueline C Bresnahan; Diana L Farmer
Journal:  Stem Cells Transl Med       Date:  2015-04-24       Impact factor: 6.940

Review 5.  Fetal surgery for spina bifida: past, present, future.

Authors:  N Scott Adzick
Journal:  Semin Pediatr Surg       Date:  2013-02       Impact factor: 2.754

Review 6.  Prenatal Neural Tube Anomalies: A Decade of Intrauterine Stem Cell Transplantation Using Advanced Tissue Engineering Methods.

Authors:  Alireza Soltani Khaboushan; Mehdi Shakibaei; Abdol-Mohammad Kajbafzadeh; Masoumeh Majidi Zolbin
Journal:  Stem Cell Rev Rep       Date:  2021-03-19       Impact factor: 5.739

7.  Fetoscopic repair of spina bifida: safer and better?

Authors:  D A L Pedreira; E A Reece; R H Chmait; E V Kontopoulos; R A Quintero
Journal:  Ultrasound Obstet Gynecol       Date:  2016-08       Impact factor: 7.299

Review 8.  Spina bifida.

Authors:  Andrew J Copp; N Scott Adzick; Lyn S Chitty; Jack M Fletcher; Grayson N Holmbeck; Gary M Shaw
Journal:  Nat Rev Dis Primers       Date:  2015-04-30       Impact factor: 52.329

9.  Magnetic resonance imaging in the prenatal diagnosis of neural tube defects.

Authors:  A Zugazaga Cortazar; C Martín Martinez; C Duran Feliubadalo; M R Bella Cueto; L Serra
Journal:  Insights Imaging       Date:  2013-03-01

10.  Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model.

Authors:  Md Sakirul Islam Khan; Hiroaki Nabeka; Farzana Islam; Tetsuya Shimokawa; Shouichiro Saito; Xuan Li; Soichiro Kawabe; Fumihiko Hamada; Tetsuya Tachibana; Seiji Matsuda
Journal:  Dis Model Mech       Date:  2017-12-19       Impact factor: 5.758
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.