OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.
OBJECTIVE: The purpose of our study was to determine whether prenatal repair of myelomeningocele prevents or reverses hindbrain herniation in the sheep model. STUDY DESIGN: A myelomeningocele was surgically created in fetal sheep. One group was repaired later in utero; the others were delivered without repair. After delivery, lambs were assessed for the presence of hindbrain herniation. RESULTS: In all lambs that had not undergone repair of the myelomeningocele, severe hindbrain herniation developed, whereas the brains of all lambs that had undergone fetal repair were normal. CONCLUSION: Prenatal repair of myelomeningocele prevents or reverses development of hindbrain herniation in the fetal lamb model.
Authors: T Kohl; M G Hartlage; D Kiehitz; M Westphal; T Buller; S Achenbach; S Aryee; U Gembruch; A Brentrup Journal: Surg Endosc Date: 2003-05-13 Impact factor: 4.584
Authors: Jyoji Yoshizawa; Lourenco Sbragia; Bettina W Paek; Roman M Sydorak; Yoji Yamazaki; Michael R Harrison; Diana L Farmer Journal: Pediatr Surg Int Date: 2003-12-20 Impact factor: 1.827
Authors: Jose Luis Encinas Hernández; C Soto; M A García-Cabezas; F Pederiva; M Garriboli; R Rodríguez; J L Peiró; F Carceller; M López-Santamaría; J A Tovar Journal: Pediatr Surg Int Date: 2008-12 Impact factor: 1.827