Literature DB >> 22325031

GB virus C: the good boy virus?

Nirjal Bhattarai1, Jack T Stapleton.   

Abstract

GB virus C (GBV-C) is a lymphotropic human virus discovered in 1995 that is related to hepatitis C virus (HCV). GBV-C infection has not been convincingly associated with any disease; however, several studies found an association between persistent GBV-C infection and improved survival in HIV-positive individuals. GBV-C infection modestly alters T cell homeostasis in vivo through various mechanisms, including modulation of chemokine and cytokine release and receptor expression, and by diminution of T cell activation, proliferation and apoptosis, all of which may contribute to improved HIV clinical outcomes. In vitro studies confirm these clinical observations and demonstrate an anti-HIV replication effect of GBV-C. This review summarizes existing data on potential mechanisms by which GBV-C interferes with HIV, and the research needed to capitalize on this epidemiological observation. Published by Elsevier Ltd.

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Year:  2012        PMID： 22325031      PMCID： PMC3477489          DOI： 10.1016/j.tim.2012.01.004

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  77 in total

1.  GB virus C infection and non-Hodgkin lymphoma: important to know but the jury is out.

Authors:  Jack T Stapleton; Kathryn Chaloner
Journal:  Int J Cancer       Date:  2010-06-15       Impact factor: 7.396

2.  Type I interferon production is profoundly and transiently impaired in primary HIV-1 infection.

Authors:  Isabelle Kamga; Sandrine Kahi; Leyla Develioglu; Miriam Lichtner; Concepción Marañón; Christiane Deveau; Laurence Meyer; Cécile Goujard; Pierre Lebon; Martine Sinet; Anne Hosmalin
Journal:  J Infect Dis       Date:  2005-06-15       Impact factor: 5.226

3.  Analysis of HIV-1 fusion peptide inhibition by synthetic peptides from E1 protein of GB virus C.

Authors:  Maria Jesús Sánchez-Martín; Kalina Hristova; Montserrat Pujol; Maria J Gómara; Isabel Haro; M Asunción Alsina; M Antònia Busquets
Journal:  J Colloid Interface Sci       Date:  2011-04-24       Impact factor: 8.128

4.  Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.

Authors:  Yvonne Koedel; Kristin Eissmann; Holger Wend; Bernhard Fleckenstein; Heide Reil
Journal:  J Virol       Date:  2011-05-04       Impact factor: 5.103

5.  Effect of GB virus C on response to antiretroviral therapy in HIV-infected Brazilians.

Authors:  I E Souza; W Zhang; R S Diaz; K Chaloner; D Klinzman; J T Stapleton
Journal:  HIV Med       Date:  2006-01       Impact factor: 3.180

6.  GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates.

Authors:  Emma L Mohr; Jinhua Xiang; James H McLinden; Thomas M Kaufman; Qing Chang; David C Montefiori; Donna Klinzman; Jack T Stapleton
Journal:  J Immunol       Date:  2010-09-08       Impact factor: 5.422

Review 7.  Role of interleukin-2 in patients with HIV infection.

Authors:  Sarah L Pett; Anthony D Kelleher; Sean Emery
Journal:  Drugs       Date:  2010-06-18       Impact factor: 9.546

8.  GB virus C coinfection in advanced HIV type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4(+) T-cells.

Authors:  Carolynne Schwarze-Zander; Markus Neibecker; Sabrina Othman; Cristina Tural; Bonaventura Clotet; Jason T Blackard; Bernd Kupfer; Guido Luechters; Ray T Chung; Jürgen K Rockstroh; Ulrich Spengler
Journal:  Antivir Ther       Date:  2010

Review 9.  Interleukin 2 in cancer therapy.

Authors:  G K Antony; A Z Dudek
Journal:  Curr Med Chem       Date:  2010       Impact factor: 4.530

Review 10.  The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae.

Authors:  Jack T Stapleton; Steven Foung; A Scott Muerhoff; Jens Bukh; Peter Simmonds
Journal:  J Gen Virol       Date:  2010-11-17       Impact factor: 3.891
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  59 in total

Review 1.  Tropism of human pegivirus (formerly known as GB virus C/hepatitis G virus) and host immunomodulation: insights into a highly successful viral infection.

Authors:  Ernest T Chivero; Jack T Stapleton
Journal:  J Gen Virol       Date:  2015-02-09       Impact factor: 3.891

Review 2.  Move over, bacteria! Viruses make their mark as mutualistic microbial symbionts.

Authors:  Marilyn J Roossinck
Journal:  J Virol       Date:  2015-04-22       Impact factor: 5.103

Review 3.  A novel T cell evasion mechanism in persistent RNA virus infection.

Authors:  Jack T Stapleton; Jinhua Xiang; James H McLinden; Nirjal Bhattarai; Ernest T Chivero; Donna Klinzman; Thomas M Kaufman; Qing Chang
Journal:  Trans Am Clin Climatol Assoc       Date:  2014

4.  GBV-C infection and risk of NHL among U.S. adults.

Authors:  Cindy M Chang; Jack T Stapleton; Donna Klinzman; James H McLinden; Mark P Purdue; Hormuzd A Katki; Eric A Engels
Journal:  Cancer Res       Date:  2014-08-12       Impact factor: 12.701

5.  [Detection of a novel human pegivirus HPgV-2 in healthy blood donors and recipients of multiple transfusions: implications for blood safety].

Authors:  Naling Zhu; Ru Xu; Weiping Tang; Haiying Wang; Zhengwei Wan; Xuedong Wu; Yongshui Fu; Shixing Tang; Shouyi Yu
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2018-07-30

6.  Human pegivirus (HPgV) infection in Ghanaians co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV).

Authors:  Kombo F N'Guessan; Ceejay Boyce; Awewura Kwara; Timothy N A Archampong; Margaret Lartey; Kwamena W Sagoe; Ernest Kenu; Adjoa Obo-Akwa; Jason T Blackard
Journal:  Virus Genes       Date:  2018-03-17       Impact factor: 2.332

7.  GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways.

Authors:  Nirjal Bhattarai; James H McLinden; Jinhua Xiang; Thomas M Kaufman; Jack T Stapleton
Journal:  J Immunol       Date:  2012-07-27       Impact factor: 5.422

8.  It takes more than two for this tango.

Authors:  Leonid Margolis
Journal:  Cell Host Microbe       Date:  2013-01-16       Impact factor: 21.023

9.  Chimpanzee GB virus C and GB virus A E2 envelope glycoproteins contain a peptide motif that inhibits human immunodeficiency virus type 1 replication in human CD4⁺ T-cells.

Authors:  James H McLinden; Jack T Stapleton; Donna Klinzman; Krishna K Murthy; Qing Chang; Thomas M Kaufman; Nirjal Bhattarai; Jinhua Xiang
Journal:  J Gen Virol       Date:  2013-01-03       Impact factor: 3.891

10.  GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.

Authors:  Nirjal Bhattarai; James H McLinden; Jinhua Xiang; Alan L Landay; Ernest T Chivero; Jack T Stapleton
Journal:  J Immunol       Date:  2013-05-17       Impact factor: 5.422
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