Literature DB >> 22324508

Introduction: use of radioactive compounds in drug discovery and development.

F Peter Guengerich.   

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Year:  2012        PMID： 22324508      PMCID： PMC3979328          DOI： 10.1021/tx3000522

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


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  9 in total

1.  Use of radiolabeled compounds in drug metabolism and pharmacokinetic studies.

Authors:  Emre M Isin; Charles S Elmore; Göran N Nilsson; Richard A Thompson; Lars Weidolf
Journal:  Chem Res Toxicol       Date:  2012-02-28       Impact factor: 3.739

2.  Strategies at the interface of drug discovery and development: early optimization of the solid state phase and preclinical toxicology formulation for potential drug candidates.

Authors:  Michael Palucki; John D Higgins; Elizabeth Kwong; Allen C Templeton
Journal:  J Med Chem       Date:  2010-08-26       Impact factor: 7.446

Review 3.  Radiolabeled absorption, distribution, metabolism, and excretion studies in drug development: why, when, and how?

Authors:  Natalia Penner; Lin Xu; Chandra Prakash
Journal:  Chem Res Toxicol       Date:  2012-02-21       Impact factor: 3.739

Review 4.  Use of radioactive compounds and autoradiography to determine drug tissue distribution.

Authors:  Eric G Solon
Journal:  Chem Res Toxicol       Date:  2012-02-09       Impact factor: 3.739

5.  Introduction: Human metabolites in safety testing (MIST) issue.

Authors:  F Peter Guengerich
Journal:  Chem Res Toxicol       Date:  2009-02       Impact factor: 3.739

Review 6.  Drug metabolite profiling and identification by high-resolution mass spectrometry.

Authors:  Mingshe Zhu; Haiying Zhang; W Griffith Humphreys
Journal:  J Biol Chem       Date:  2011-06-01       Impact factor: 5.157

7.  Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.

Authors:  Donglu Zhang; Oliver Flint; Lifei Wang; Ashok Gupta; Richard A Westhouse; Weiping Zhao; Nirmala Raghavan; Janet Caceres-Cortes; Punit Marathe; Guoxiang Shen; Yueping Zhang; Alban Allentoff; Jonathan Josephs; Jinping Gan; Robert Borzilleri; W Griffith Humphreys
Journal:  Chem Res Toxicol       Date:  2012-03-02       Impact factor: 3.739

8.  Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.

Authors:  Abdul Mutlib; Robert Espina; James Atherton; Jianyao Wang; Rasmy Talaat; JoAnn Scatina; Appavu Chandrasekaran
Journal:  Chem Res Toxicol       Date:  2012-02-10       Impact factor: 3.739

Review 9.  Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?

Authors:  R Scott Obach; Angus N Nedderman; Dennis A Smith
Journal:  Xenobiotica       Date:  2011-10-12       Impact factor: 1.908
  9 in total
  1 in total

1.  Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity.

Authors:  Kristyna Krasulova; Ondrej Holas; Pavel Anzenbacher
Journal:  Molecules       Date:  2017-11-03       Impact factor: 4.411
  1 in total

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