| Literature DB >> 22323219 |
Lorenza Bordoli1, Torsten Schwede.
Abstract
Comparative protein structure modeling is a computational approach to build three-dimensional structural models for proteins using experimental structures of related protein family members as templates. Regular blind assessments of modeling accuracy have demonstrated that comparative protein structure modeling is currently the most reliable technique to model protein structures. Homology models are often sufficiently accurate to substitute for experimental structures in a wide variety of applications. Since the usefulness of a model for specific application is determined by its accuracy, model quality estimation is an essential component of protein structure prediction. Comparative protein modeling has become a routine approach in many areas of life science research since fully automated modeling systems allow also nonexperts to build reliable models. In this chapter, we describe practical approaches for automated protein structure modeling with SWISS-MODEL Workspace and the Protein Model Portal.Entities:
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Year: 2012 PMID： 22323219 PMCID： PMC5651980 DOI： 10.1007/978-1-61779-588-6_5
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745