| Literature DB >> 22322890 |
Juan Li1, Bin Liu, Xiaofei Gao, Zhixing Ma, Tianyi CaoSong, Yan-ai Mei, Yufang Zheng.
Abstract
The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. One of those signaling processes is ADAM17- and ADAM10-dependent ectodomain shedding. By using an alkaline phosphatase tagged substrate reporter system, we have shown that ADAM10-dependent BTC shedding was very sensitive to both membrane lipid component change and sigma-1 receptor agonist DHEAS treatment while ADAM17-dependent HB-EGF shedding was not; and overexpression of sigma-1 receptor diminished ADAM17- and ADAM10-dependent shedding. Our results indicate that sigma-1 receptor plays an important role in modifying the function of transmembrane proteases.Entities:
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Year: 2012 PMID： 22322890 PMCID： PMC4875409 DOI： 10.1007/s13238-012-2006-9
Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870